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A novel graphene nanosheets coated stainless steel fiber for microwave assisted headspace solid phase microextraction of organochlorine pesticides in aqueous samples followed by gas chromatography with electron capture detection 2011 Department of Chemistry, National Chung-Hsing University, Taichung 402, Taiwan.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of chromatography.A
Periodical, Abbrev.
J.Chromatogr.A
Pub Date Free Form
28-Sep
Volume
1218
Issue
39
Start Page
6861
Other Pages
6868
Notes
CI: Copyright (c) 2011; JID: 9318488; 0 (Hydrocarbons, Chlorinated); 0 (Pesticides); 0 (Water Pollutants, Chemical); 12597-68-1 (Stainless Steel); 7782-42-5 (Graphite); 2011/04/15 [received]; 2011/08/08 [revised]; 2011/08/08 [accepted]; 2011/08/16 [aheado
Place of Publication
Netherlands
ISSN/ISBN
1873-3778; 0021-9673
Accession Number
PMID: 21872868
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.chroma.2011.08.019 [doi]
Output Language
Unknown(0)
PMID
21872868
Abstract
In this study, a novel graphene nanosheets (GNSs) coated solid phase microextraction (SPME) fiber was prepared by immobilizing microwave synthesized GNSs on a stainless steel wire. Microwave synthesized GNSs were verified by X-ray diffraction, field emission-scanning electron microscopy (FE-SEM) and transmission electron microscope (TEM). GNS-SPME fiber was characterized using FE-SEM and the results showed the GNS coating was homogeneous, porous, and highly adherent to the surface of the stainless steel fiber. The performance and feasibility of the GNS-SPME fiber was evaluated under one-step microwave assisted (MA) headspace (HS) SPME followed by gas chromatography with electron capture detection for five organochlorine pesticides (OCPs) in aqueous samples. Parameters influencing the extraction efficiency of MA-HS-GNS-SPME such as microwave irradiation power and time, pH, ionic strength, and desorption conditions were thoroughly examined. Under the optimized conditions, detection limits for the OCPs varied between 0.16 and 0.93 ng L(-1) and linear ranges varied between 1 and 1500 n gL(-1), with correlation coefficients ranging from 0.9984 to 0.9998, and RSDs in the range of 3.6-15.8% (n=5). In comparison with the commercial 100 mum polydimethylsiloxane fiber, the GNS coated fiber showed better extraction efficiency, higher mechanical and thermal stability (up to 290 degrees C), longer life span (over 250 times), and lower production cost. The method was successfully applied to the analysis of real water samples with recoveries ranged between 80.1 and 101.1% for river water samples. The results demonstrated that the developed MA-HS-GNS-SPME method was a simple, rapid, efficient pretreatment and environmentally friendly procedure for the analysis of OCPs in aqueous samples.
Descriptors
Links
Book Title
Database
Publisher
Elsevier B.V
Data Source
Authors
Ponnusamy,V.K., Jen,J.F.
Original/Translated Title
URL
Date of Electronic
20110816
PMCID
Editors
A novel IS26 structure surrounds blaCTX-M genes in different plasmids from German clinical Escherichia coli isolates 2010 Robert Koch Institute, Burgstrasse 37, 38855 Wernigerode, Germany. cullika@rki.de
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of medical microbiology
Periodical, Abbrev.
J.Med.Microbiol.
Pub Date Free Form
May
Volume
59
Issue
Pt 5
Start Page
580
Other Pages
587
Notes
JID: 0224131; 0 (DNA Transposable Elements); 0 (Escherichia coli Proteins); EC 3.5.2.6 (beta-Lactamases); 2010/01/21 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1473-5644; 0022-2615
Accession Number
PMID: 20093380
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1099/jmm.0.016188-0 [doi]
Output Language
Unknown(0)
PMID
20093380
Abstract
This report focuses on the molecular characterization of 22 extended-spectrum beta-lactamase-producing Escherichia coli isolates collected in a German university hospital during a period of 9 months in 2006. Relationship analysis of clinical isolates was done via PFGE, multilocus sequence typing, plasmid profiling and additionally PCR for bla(ESBL) detection and determination of phylogroups. After conjugal transfer, plasmid isolation and subsequent PCR for bla(ESBL) detection and determination of incompatibility groups were performed. Using one-primer walking, up to 3600 bp upstream and downstream of different bla(CTX-M) genes could be sequenced. beta-Lactamases found were TEM-1 (n=14), SHV-5 (n=1) and a wide variety of CTX-M types (n=21), i.e. CTX-M-15 (n=12), CTX-M-1 (n=4), CTX-M-14 (n=2), CTX-M-9 (n=1), CTX-M-3 (n=1) and one new type, CTX-M-65 (n=1). In 18 isolates, bla(ESBL) genes were located on conjugative plasmids of sizes between 40 and 180 kbp belonging to incompatibility groups FII (n=9), N (n=5) and I1 (n=4). bla(CTX-M) was found to be associated with the common elements ISEcp1, IS26 and IS903-D, but with unusual spacer sequences for ISEcp1 in two isolates. These insertion sequences, connected to bla(CTX-M) as well as other genes, were located between two IS26 elements in a configuration that has not yet been described. The results reveal the emergence of bla(ESBL), predominantly bla(CTX-M), located on different plasmids harboured by genotypically different E. coli strains. The identical gene arrangement in the bla(CTX-M) neighbourhood in plasmids of different incompatibility groups indicates a main role of IS26 in distribution of mobile resistance elements between different plasmids.
Descriptors
Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Typing Techniques, Child, Child, Preschool, Conjugation, Genetic, DNA Fingerprinting, DNA Transposable Elements, Electrophoresis, Gel, Pulsed-Field, Escherichia coli/genetics/isolation & purification, Escherichia coli Infections/microbiology, Escherichia coli Proteins/genetics, Female, Genotype, Germany, Hospitals, University, Humans, Infant, Infant, Newborn, Male, Middle Aged, Plasmids, Sequence Analysis, DNA, Young Adult, beta-Lactamases/genetics
Links
Book Title
Database
Publisher
Data Source
Authors
Cullik,A., Pfeifer,Y., Prager,R., von Baum,H., Witte,W.
Original/Translated Title
URL
Date of Electronic
20100121
PMCID
Editors
A novel multiwalled carbon nanotubes bonded fused-silica fiber for solid phase microextraction-gas chromatographic analysis of phenols in water samples 2009 Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Talanta
Periodical, Abbrev.
Talanta
Pub Date Free Form
15-May
Volume
78
Issue
3
Start Page
929
Other Pages
935
Notes
LR: 20131121; JID: 2984816R; 0 (Nanotubes, Carbon); 0 (Phenols); 059QF0KO0R (Water); 7631-86-9 (Silicon Dioxide); 2008/11/04 [received]; 2008/12/23 [revised]; 2008/12/30 [accepted]; 2009/01/20 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1873-3573; 0039-9140
Accession Number
PMID: 19269452
Language
eng
SubFile
Evaluation Studies; Journal Article; IM
DOI
10.1016/j.talanta.2008.12.061 [doi]
Output Language
Unknown(0)
PMID
19269452
Abstract
The present work reports on the synthesis of chemically bonded multiwalled carbon nanotubes (MWCNTs)/fused-silica fibers and their use in solid phase microextraction of seven phenols from water samples coupled with gas chromatography (GC). The synthetic strategy was verified by infrared (IR) spectroscopy and field emission scanning electron microscopy. Adsorption factors (pH, ionic strength, stirring rate, adsorption time and temperature) and desorption factors (time and temperature) of the fibers were systematically investigated. Detection limits to seven phenols were less than 0.05 microg L(-1), and their calibration curves were all linear (R(2)> or =0.9984) in the range from 0.05 to 5000 microg L(-1). This method was then utilized to analyze two real water samples from Yellow River and sanitary wastewater, resulting in satisfactory results. Compared with normal solid phase materials, this MWCNTs-bonded fused-silica fibers showed a number of advantages: wide linear range and low detection limit for extracting phenols couple with GC, and good stability in acid, alkali, organic solvents and at high temperature.
Descriptors
Chromatography, Gas/methods, Nanotubes, Carbon, Phenols/analysis, Silicon Dioxide, Solid Phase Microextraction/methods, Water/analysis
Links
Book Title
Database
Publisher
Data Source
Authors
Liu,H., Li,J., Liu,X., Jiang,S.
Original/Translated Title
URL
Date of Electronic
20090120
PMCID
Editors
A novel real-time PCR assay for the specific identification and quantification of Weissella viridescens in blood sausages 2015 Department of Biotechnology and Food Science, University of Burgos, Pza. Misael Banuelos s/n, 09001, Burgos, Spain. Electronic address: emgomez@ubu.es.; Department of Advanced Materials, Nuclear Technology and Applied Nano/Biotechnology, University of Bur
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
International journal of food microbiology
Periodical, Abbrev.
Int.J.Food Microbiol.
Pub Date Free Form
23-Dec
Volume
215
Issue
Start Page
16
Other Pages
24
Notes
CI: Copyright (c) 2015; JID: 8412849; 0 (DNA Primers); OTO: NOTNLM; 2015/05/17 [received]; 2015/08/04 [revised]; 2015/08/07 [accepted]; 2015/08/16 [aheadofprint]; ppublish
Place of Publication
Netherlands
ISSN/ISBN
1879-3460; 0168-1605
Accession Number
PMID: 26318409
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.ijfoodmicro.2015.08.002 [doi]
Output Language
Unknown(0)
PMID
26318409
Abstract
Weissella viridescens has been identified as one of the lactic acid bacteria (LAB) responsible for the spoilage of "morcilla de Burgos". In order to identify and quantify this bacterium in "morcilla de Burgos", a new specific PCR procedure has been developed. The primers and Taqman probe were designed on the basis of a sequence from the gene recN. To confirm the specificity of the primers, 77 strains from the genera Carnobacterium, Enterococcus, Lactobacillus, Leuconostoc, Pediococcus, Streptococcus, Vagococcus and Weissella were tested by conventional PCR. The specificity of the primers and the correct functioning of the probe was confirmed by performing real-time PCR (qPCR) with 21 W. viridescens strains and 27 strains from other LAB genera. The levels of detection and quantification for the qPCR procedure proposed herein were determined for a pure culture of W. viridescens CECT 283(T) and for "morcilla de Burgos" artificially inoculated with this species. The primers were specific for W. viridescens, with only one product of 91 bp being observed for this species. Similarly, the qPCR reactions were found to be specific, amplifying at a mean CT of 15.0+/-0.4 only for W. viridescens strains. The limit of detection (LOD) and quantification (LOQ) for this procedure was established in 0.082 pg for genomic DNA from W. viridescens. With regard to the artificially inoculated "morcilla", the limit of quantification was established in 80 CFU/reaction and the limit of detection in 8 CFU/reaction. Consequently, the qPCR developed herein can be considered to be a good, fast, simple and accurate tool for the specific detection and quantification of W. viridescens in meat samples.
Descriptors
Links
Book Title
Database
Publisher
Elsevier B.V
Data Source
Authors
Gomez-Rojo,E.M., Romero-Santacreu,L., Jaime,I., Rovira,J.
Original/Translated Title
URL
Date of Electronic
20150816
PMCID
Editors
A novel solid-phase microextraction using coated fiber based sol-gel technique using poly(ethylene glycol) grafted multi-walled carbon nanotubes for determination of benzene, toluene, ethylbenzene and o-xylene in water samples with gas chromatography-flam 2011 Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Iran. asyazdi@um.ac.ir
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of chromatography.A
Periodical, Abbrev.
J.Chromatogr.A
Pub Date Free Form
26-Aug
Volume
1218
Issue
34
Start Page
5757
Other Pages
5764
Notes
LR: 20151119; CI: Copyright (c) 2011; JID: 9318488; 0 (Benzene Derivatives); 0 (Nanotubes, Carbon); 0 (Water Pollutants, Chemical); 0 (Xylenes); 30IQX730WE (Polyethylene Glycols); 3FPU23BG52 (Toluene); J64922108F (Benzene); L5I45M5G0O (ethylbenzene); Z247
Place of Publication
Netherlands
ISSN/ISBN
1873-3778; 0021-9673
Accession Number
PMID: 21782185
Language
eng
SubFile
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.chroma.2011.06.099 [doi]
Output Language
Unknown(0)
PMID
21782185
Abstract
In this study, poly(ethylene glycol) (PEG) grafted onto multi-walled carbon nanotubes (PEG-g-MWCNTs) were synthesized by the covalent functionalization of MWCNTs with hydroxyl-terminated PEG chains. For the first time, functionalized product of PEG-g-MWCNTs was used as selective stationary phase to prepare the sol-gel solid-phase microextraction (SPME) fiber in combination with gas chromatography-flame ionization detector (GC-FID) for the determination of ultra-trace levels of benzene, toluene, ethylbenzene and o-xylene (BTEX) in real water samples. The PEG-g-MWCNTs were characterized by Fourier transform infrared spectra and also thermo-gravimetric analysis, which verified that PEG chains were grafted onto the surface of the MWCNTs. The scanning electron micrographs of the fiber surface revealed a highly porous structure which greatly increases the surface area for PEG-g-MWCNTs sol-gel coating. This fiber demonstrated many inherent advantages, the main being the strong anchoring of the coating to the fused silica resulting from chemical bonding with the silanol groups on the fused-silica fiber surface. The new PEG-g-MWCNTs sol-gel fiber is simple to prepare, robust, with high thermal stability and long lifetime, up to 200 extractions. Important parameters influencing the extraction efficiency such as desorption temperature and time, extraction temperature, extraction time, stirring speed and salt effect were investigated and optimized. Under the optimal conditions, the method detection limits (S/N=3) were in the range of 0.6-3 pg mL(-1) and the limits of quantification (S/N=10) between 2 and 10 pg mL(-1). The relative standard deviations (RSDs) for one fiber (repeatability) (n=5) were obtained from 4.40 up to 5.75% and between fibers or batch to batch (n=3) (reproducibility) in the range of 4.31-6.55%. The developed method was successfully applied to real water samples while the relative recovery percentages obtained for the spiked water samples at 20 pg mL(-1) were from 90.21 to 101.90%.
Descriptors
Links
Book Title
Database
Publisher
Elsevier B.V
Data Source
Authors
Sarafraz-Yazdi,A., Amiri,A., Rounaghi,G., Hosseini,H.E.
Original/Translated Title
URL
Date of Electronic
20110703
PMCID
Editors
A novel TiO2 nanotube array/Ti wire incorporated solid-phase microextraction fiber with high strength, efficiency and selectivity 2010 Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No. 18 Tianshui Road, Lanzhou 730000, China.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of chromatography.A
Periodical, Abbrev.
J.Chromatogr.A
Pub Date Free Form
19-Mar
Volume
1217
Issue
12
Start Page
1898
Other Pages
1903
Notes
LR: 20131121; CI: Copyright 2010; JID: 9318488; 0 (Alkanes); 0 (Polycyclic Hydrocarbons, Aromatic); 059QF0KO0R (Water); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium); 2009/12/04 [received]; 2010/01/21 [revised]; 2010/01/27 [accepted]; 2010/02/02 [a
Place of Publication
Netherlands
ISSN/ISBN
1873-3778; 0021-9673
Accession Number
PMID: 20153861
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1016/j.chroma.2010.01.080 [doi]
Output Language
Unknown(0)
PMID
20153861
Abstract
A novel solid-phase microextraction (SPME) fiber is fabricated through the anodization of Ti wire substrates in an electrolyte containing ethylene glycol and NH(4)F. By a combination of field emission scanning electron microscope and X-ray photoelectron spectroscope studies, it is shown that perpendicularly orientated and well-aligned TiO(2) nanotubes are grown in situ on the Ti wire substrate. The SPME fiber coupled with gas chromatograph (GC) is then used to extract polycyclic aromatic hydrocarbons (PAHs), anilines, phenols, and alkanes from standard and real water samples, and exhibits high selectivity for PAHs. After the optimization of adsorption factors (pH, ionic strength, time and temperature) and desorption factors (time and temperature) of the SPME fiber for PAHs, the limit of detection (LOD) of less than 0.1 microg L(-1) is achieved, and the calibration curves are all linear (R(2)> or =0.9898) in the range from 0.1 to 1000 microg L(-1). Beyond that, the SPME fiber has high strength, large surface area, good stability at high temperature and in acid and alkali solutions, and long service life, making it have strong application potentials in the selective extraction of PAHs from complex samples at trace levels.
Descriptors
Adsorption, Alkanes/isolation & purification, Chromatography, Gas, Electrodes, Limit of Detection, Nanotubes/chemistry/ultrastructure, Osmolar Concentration, Photoelectron Spectroscopy, Polycyclic Hydrocarbons, Aromatic/isolation & purification, Solid Phase Microextraction/instrumentation, Surface Properties, Temperature, Time Factors, Titanium/chemistry, Water/chemistry
Links
Book Title
Database
Publisher
Elsevier B.V
Data Source
Authors
Liu,H., Wang,D., Ji,L., Li,J., Liu,S., Liu,X., Jiang,S.
Original/Translated Title
URL
Date of Electronic
20100202
PMCID
Editors
A pattern-matched Twitter analysis of US cancer-patient sentiments 2016 Department of Surgery, University of Vermont College of Medicine, Burlington, Vermont.; Department of Surgery, University of Vermont College of Medicine, Burlington, Vermont; Department of Mathematics and Statistics, University of Vermont, College of Engi
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Journal of surgical research
Periodical, Abbrev.
J.Surg.Res.
Pub Date Free Form
25-Jun
Volume
Issue
Start Page
Other Pages
Notes
LR: 20160815; CI: Copyright (c) 2016; JID: 0376340; OTO: NOTNLM; 2016/01/29 [received]; 2016/06/03 [revised]; 2016/06/09 [accepted]; aheadofprint
Place of Publication
ISSN/ISBN
1095-8673; 0022-4804
Accession Number
PMID: 27523257
Language
ENG
SubFile
JOURNAL ARTICLE
DOI
S0022-4804(16)30175-5 [pii]
Output Language
Unknown(0)
PMID
27523257
Abstract
BACKGROUND: Twitter has been recognized as an important source of organic sentiment and opinion. This study aimed to (1) characterize the content of tweets authored by the United States cancer patients; and (2) use patient tweets to compute the average happiness of cancer patients for each cancer diagnosis. METHODS: A large sample of English tweets from March 2014 through December 2014 was obtained from Twitter. Using regular expression software pattern matching, the tweets were filtered by cancer diagnosis. For each cancer-specific tweetset, individual patients were extracted, and the content of the tweet was categorized. The patients' Twitter identification numbers were used to gather all tweets for each patient, and happiness values for patient tweets were calculated using a quantitative hedonometric analysis. RESULTS: The most frequently tweeted cancers were breast (n = 15,421, 11% of total cancer tweets), lung (n = 2928, 2.0%), prostate (n = 1036, 0.7%), and colorectal (n = 773, 0.5%). Patient tweets pertained to the treatment course (n = 73, 26%), diagnosis (n = 65, 23%), and then surgery and/or biopsy (n = 42, 15%). Computed happiness values for each cancer diagnosis revealed higher average happiness values for thyroid (h_avg = 6.1625), breast (h_avg = 6.1485), and lymphoma (h_avg = 6.0977) cancers and lower average happiness values for pancreatic (h_avg = 5.8766), lung (h_avg = 5.8733), and kidney (h_avg = 5.8464) cancers. CONCLUSIONS: The study confirms that patients are expressing themselves openly on social media about their illness and that unique cancer diagnoses are correlated with varying degrees of happiness. Twitter can be employed as a tool to identify patient needs and as a means to gauge the cancer patient experience.
Descriptors
Links
Book Title
Database
Publisher
Elsevier Inc
Data Source
Authors
Crannell,W.C., Clark,E., Jones,C., James,T.A., Moore,J.
Original/Translated Title
URL
Date of Electronic
20160625
PMCID
Editors
A persisting secondhand smoke hazard in urban public places: results from fine particulate (PM2.5) air sampling 2011 Department of Public Health, University of Otago Wellington, PO Box 7343 Wellington South, New Zealand. nick.wilson@otago.ac.nz
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The New Zealand medical journal
Periodical, Abbrev.
N.Z.Med.J.
Pub Date Free Form
4-Mar
Volume
124
Issue
1330
Start Page
34
Other Pages
47
Notes
JID: 0401067; 0 (Hazardous Substances); 0 (Particulate Matter); 0 (Tobacco Smoke Pollution); CIN: N Z Med J. 2011 Mar 4;124(1330):5-7. PMID: 21681245; epublish
Place of Publication
New Zealand
ISSN/ISBN
1175-8716; 0028-8446
Accession Number
PMID: 21681251
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
21681251
Abstract
AIM: To assess the need for additional smokefree settings, by measuring secondhand smoke (SHS) in a range of public places in an urban setting. METHODS: Measurements were made in Wellington City during the 6-year period after the implementation of legislation that made indoor areas of restaurants and bars/pubs smokefree in December 2004, and up to 20 years after the 1990 legislation making most indoor workplaces smokefree. Fine particulate levels (PM2.5) were measured with a portable real-time airborne particle monitor. We collated data from our previously published work involving random sampling, purposeful sampling and convenience sampling of a wide range of settings (in 2006) and from additional sampling of selected indoor and outdoor areas (in 2007-2008 and 2010). RESULTS: The "outdoor" smoking areas of hospitality venues had the highest particulate levels, with a mean value of 72 mcg/m3 (range of maximum values 51-284 mcg/m3) (n=20 sampling periods). These levels are likely to create health hazards for some workers and patrons (i.e., when considered in relation to the WHO air quality guidelines). National survey data also indicate that these venues are the ones where SHS exposure is most frequently reported by non-smokers. Areas inside bars that were adjacent to "outdoor" smoking areas also had high levels, with a mean of 54 mcg/m3 (range of maximum values: 18-239 mcg/m3, for n=13 measurements). In all other settings mean levels were lower (means: 2-22 mcg/m3). These other settings included inside traditional style pubs/sports bars (n=10), bars (n=18), restaurants (n=9), cafes (n=5), inside public buildings (n=15), inside transportation settings (n=15), and various outdoor street/park settings (n=22). During the data collection in all settings made smokefree by law, there was only one occasion of a person observed smoking. CONCLUSIONS: The results suggest that compliance in pubs/bars and restaurants has remained extremely high in this city in the nearly six years since implementation of the upgraded smokefree legislation. The results also highlight additional potential health gain from extending smokefree policies to reduce SHS exposure in the "outdoor" smoking areas of hospitality venues and to reduce SHS drift from these areas to indoor areas.
Descriptors
Links
Book Title
Database
Publisher
Data Source
Authors
Wilson,N., Edwards,R., Parry,R.
Original/Translated Title
URL
Date of Electronic
20110304
PMCID
Editors
A pilot clinical trial of varenicline for smoking cessation in black smokers 2011 Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS 66160, USA. nnollen@kumc.edu
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Sep
Volume
13
Issue
9
Start Page
868
Other Pages
873
Notes
LR: 20151119; GR: P60MD003422/MD/NIMHD NIH HHS/United States; JID: 9815751; 0 (Benzazepines); 0 (Nicotinic Agonists); 0 (Quinoxalines); W6HS99O8ZO (Varenicline); OID: NLM: PMC3203399; 2011/04/15 [aheadofprint]; ppublish
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 21498427
Language
eng
SubFile
Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM
DOI
10.1093/ntr/ntr063 [doi]
Output Language
Unknown(0)
PMID
21498427
Abstract
INTRODUCTION: Varenicline, a first-line non-nicotine medication, has not been evaluated in Black smokers, and limited attention has been paid to pharmacotherapy adherence in smoking cessation trials. This pilot study estimated quit rates for Black smokers treated with varenicline and tested a behavioral intervention to aid varenicline adherence. METHODS: Seventy-two Black smokers (>10 cigarettes per day; cpd) were randomly assigned to adherence support (AS; n = 36) or standard care (n = 36). All participants received 3 months of varenicline and a single counseling session focused on making a quit plan. AS participants received 5 additional counseling sessions to encourage medication use. Outcome measures included salivary cotinine, and carbon monoxide confirmed smoking abstinence, reductions in self-reported cpd, and pill counts of varenicline adherence at Months 1, 2, and 3. RESULTS: Sixty-one participants (84.7%) completed follow-up at Month 3. Participants were female (62.5%), 46.8 years of age, and smoked 16.3 cpd. No treatment group differences were found on the smoking or adherence outcome measures (p > .05). Collapsing across treatment, varenicline adherence was adequate (86.1%), yet despite a reduction of 12.2 (6.5) cpd from baseline to Month 3 (p < 0.001), only 23.6% were confirmed quit at Month 3. Participants who were quit at Month 3 had higher varenicline adherence rates (95.8%) than those who continued to smoke (80.8%, p </= .05). CONCLUSIONS: Studies are needed to examine the efficacy of varenicline among Black smokers. Interventions to facilitate adherence to pharmacotherapy warrant further attention as adherence is linked to improved tobacco abstinence.
Descriptors
Adult, African Americans, Behavior Therapy, Benzazepines/administration & dosage, Combined Modality Therapy, Counseling/methods, Female, Humans, Male, Medication Adherence, Middle Aged, Nicotinic Agonists/administration & dosage, Pilot Projects, Quinoxalines/administration & dosage, Smoking Cessation/ethnology/methods, Tobacco Use Disorder/drug therapy/ethnology, United States, Varenicline
Links
Book Title
Database
Publisher
Data Source
Authors
Nollen,N. L., Cox,L. S., Nazir,N., Ellerbeck,E. F., Owen,A., Pankey,S., Thompson,N., Ahluwalia,J. S.
Original/Translated Title
URL
Date of Electronic
20110415
PMCID
PMC3203399
Editors
A pilot randomized study of smokeless tobacco use among smokers not interested in quitting: changes in smoking behavior and readiness to quit 2010 Department of Psychiatry, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, P.O. Box 250955, Charleston, SC 29425, USA. carpente@musc.edu
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Periodical, Abbrev.
Nicotine Tob.Res.
Pub Date Free Form
Feb
Volume
12
Issue
2
Start Page
136
Other Pages
143
Notes
LR: 20151119; GR: K12 DA000357/DA/NIDA NIH HHS/United States; GR: K12 DA000357/DA/NIDA NIH HHS/United States; GR: K23 DA020482/DA/NIDA NIH HHS/United States; GR: UL1 RR029882/RR/NCRR NIH HHS/United States; JID: 9815751; 6M3C89ZY6R (Nicotine); OID: NLM: PM
Place of Publication
England
ISSN/ISBN
1469-994X; 1462-2203
Accession Number
PMID: 20053788
Language
eng
SubFile
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; IM
DOI
10.1093/ntr/ntp186 [doi]
Output Language
Unknown(0)
PMID
20053788
Abstract
INTRODUCTION: Several prior studies suggest that smokeless tobacco use results in less carcinogenic risk than does cigarette smoking. Whether smokers will use smokeless tobacco is unclear, as is the impact of such use on long-term smoking behavior and cessation. It is equally plausible that smokeless tobacco use among smokers could either (a) increase total tobacco exposure and undermine motivation to quit or (b) decrease overall tobacco exposure, motivate smokers to quit, and enhance cessation. Either outcome is of major public health significance. METHODS: In this small (N = 31), short-term (2 week) pilot study, smokers uninterested in quitting were randomized to (a) receive Ariva or Stonewall (both spitless and smokeless tobacco lozenges) or (b) continue smoking conventional cigarettes. RESULTS: Ariva/Stonewall use led to a significant reduction (40%, 95% CI: 24%-55%) in cigarettes per day, no significant increases in total tobacco use (cigarettes + Ariva/Stonewall; p > .05), and significant increases in two measures of readiness to quit, either in the next month (p < .001) or within the next 6 months (p = .04), as well as significant increases in self-efficacy to quit smoking (p < .001). No such changes were found among smokers maintained on conventional cigarettes. DISCUSSION: These results suggest no deleterious effect on short-term smoking and quitting behavior among smokers who use smokeless tobacco. More broadly, this study suggests a strong need for a large prospective randomized clinical trial to more accurately assess the long-term viability of smokeless tobacco use as a method for cessation induction among unmotivated smokers.
Descriptors
Adult, Behavior, Addictive/drug therapy/prevention & control, Dose-Response Relationship, Drug, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Middle Aged, Nicotine/administration & dosage, Pilot Projects, Self Efficacy, Smoking/drug therapy, Smoking Cessation/methods, Substance Withdrawal Syndrome/prevention & control, Tobacco Use Disorder/drug therapy, Tobacco, Smokeless
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Data Source
Authors
Carpenter,M. J., Gray,K. M.
Original/Translated Title
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Date of Electronic
20100106
PMCID
PMC2816197
Editors