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Risk of decompression illness among 230 divers in relation to the presence and size of patent foramen ovale 2004 Department of Cardiology, University Hospital, CH-3010 Bern, Switzerland.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
European heart journal
Periodical, Abbrev.
Eur.Heart J.
Pub Date Free Form
Jun
Volume
25
Issue
12
Start Page
1014
Other Pages
1020
Notes
LR: 20050428; JID: 8006263; CIN: Eur Heart J. 2004 Dec;25(23):2173-4. PMID: 15571841; 2003/11/29 [received]; 2004/04/09 [revised]; 2004/04/13 [accepted]; ppublish
Place of Publication
England
ISSN/ISBN
0195-668X; 0195-668X
Accession Number
PMID: 15191771
Language
eng
SubFile
Journal Article; IM
DOI
10.1016/j.ehj.2004.04.028 [doi]
Output Language
Unknown(0)
PMID
15191771
Abstract
BACKGROUND: The risk of developing decompression illness (DCI) in divers with a patent foramen ovale (PFO) has not been directly determined so far; neither has it been assessed in relation to the PFO's size. METHODS: In 230 scuba divers (age 39+/-8 years), contrast trans-oesophageal echocardiography (TEE) was performed for the detection and size grading (0-3) of PFO. Prior to TEE, the study individuals answered a detailed questionnaire about their health status and about their diving habits and accidents. For inclusion into the study, > or =200 dives and strict adherence to decompression tables were required. RESULTS: Sixty-three divers (27%) had a PFO. Overall, the absolute risk of suffering a DCI event was 2.5 per 10(4) dives. There were 18 divers (29%) with, and 10 divers (6%) without, PFO who had experienced > or =1 major DCI events P=0.016. In the group with PFO, the incidence per 10(4) dives of a major DCI, a DCI lasting longer than 24 h and of being treated in a decompression chamber amounted to 5.1 (median 0, interquartile range [IQR] 0-10.0), 1.9 (median 0, IQR 0-4.0) and 3.6 (median 0, IQR 0-9.8), respectively and was 4.8-12.9-fold higher than in the group without PFO (P<0.001). The risk of suffering a major DCI, of a DCI lasting longer than 24 h and of being treated by recompression increased with rising PFO size. CONCLUSION: The presence of a PFO is related to a low absolute risk of suffering five major DCI events per 10(4) dives, the odds of which is five times as high as in divers without PFO. The risk of suffering a major DCI parallels PFO size.
Descriptors
Decompression Sickness/etiology/pathology, Diving/adverse effects/statistics & numerical data, Echocardiography, Transesophageal/methods, Female, Health Status, Heart Septal Defects, Atrial/complications/pathology/ultrasonography, Humans, Male, Middle Aged, Risk Assessment, Risk Factors
Links
Book Title
Database
Publisher
Data Source
Authors
Torti,S. R., Billinger,M., Schwerzmann,M., Vogel,R., Zbinden,R., Windecker,S., Seiler,C.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Smoking behaviour and increase in nicotine and carboxyhaemoglobin in venous blood 1992 Medizinische Universitatsklinik Heidelberg.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
The Clinical investigator
Periodical, Abbrev.
Clin.Investig.
Pub Date Free Form
Mar-Apr
Volume
70
Issue
4-Mar
Start Page
335
Other Pages
342
Notes
LR: 20151119; JID: 9207154; 6M3C89ZY6R (Nicotine); 7U1EE4V452 (Carbon Monoxide); 9061-29-4 (Carboxyhemoglobin); ppublish
Place of Publication
GERMANY
ISSN/ISBN
0941-0198; 0941-0198
Accession Number
PMID: 1521048
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
1521048
Abstract
The connection between smoking behaviour (number of puffs, puff volume, depth of inhalation, duration of inhalation) and the increase in both nicotine and carboxyhaemoglobin (COHb) in venous blood was investigated with methods developed especially for measurement of the puff volume, the depth of inhalation, and the duration of inhalation in 28 inhaling cigarette smokers. A significant correlation could be demonstrated between the smoking parameters and the nicotine and carboxyhaemoglobin increase. The weighting obtained shows that the number of puffs is the most important parameter affecting the increase in nicotine, whereas the depth of inhalation and the puff volume are of much less relevance. The duration of inhalation does not affect the nicotine level. A significant increase in nicotine cannot be attained in non-inhalative smoking of cigarettes with an acid mainstream smoke (n = 14). The increase in COHb is most affected by the puff volume, and slightly less by the number of puffs and the depth of inhalation. The duration of inhalation does not affect the COHb level.
Descriptors
Administration, Inhalation, Adult, Carbon Monoxide/analysis, Carboxyhemoglobin/analysis, Female, Humans, Lung Compliance, Male, Nicotine/blood/pharmacokinetics, Partial Pressure, Smoking/blood, Veins, Vital Capacity
Links
Book Title
Database
Publisher
Data Source
Authors
Rieben,F. W.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Scuba diving and the heart. Cardiac aspects of sport scuba diving 2004 Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinik fur Anasthesiologie, Universitat Ulm, Ulm. claus-martin.muth@medizin.uni-ulm.de
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Herz
Periodical, Abbrev.
Herz
Pub Date Free Form
Jun
Volume
29
Issue
4
Start Page
406
Other Pages
413
Notes
LR: 20071115; JID: 7801231; RF: 45; ppublish
Place of Publication
Germany
ISSN/ISBN
0340-9937; 0340-9937
Accession Number
PMID: 15241540
Language
ger
SubFile
English Abstract; Journal Article; Review; IM
DOI
10.1007/s00059-004-2581-5 [doi]
Output Language
Unknown(0)
PMID
15241540
Abstract
Diving with self-contained underwater breathing apparatus (scuba) has become a popular recreational sports activity throughout the world. A high prevalence of cardiovascular disorders among the population makes it therefore likely that subjects suffering from cardiovascular problems may want to start scuba diving. Although scuba diving is not a competitive sport requiring athletic health conditions, a certain medical fitness is recommended because of the physical peculiarities of the underwater environment. Immersion alone will increase cardiac preload by central blood pooling with a rise in both cardiac output and blood pressure, counteracted by increased diuresis. Exposure to cold and increased oxygen partial pressure during scuba diving will additionally increase afterload by vasoconstrictive effects and may exert bradyarryhthmias in combination with breath-holds. Volumes of gas-filled body cavities will be affected by changing pressure (Figure 1), and inert gas components of the breathing gas mixture such as nitrogen in case of air breathing will dissolve in body tissues and venous blood with increasing alveolar inert gas pressure. During decompression a free gas phase may form in supersaturated tissues, resulting in the generation of inert gas microbubbles that are eliminated by the venous return to the lungs under normal circumstances. Certain cardiovascular conditions may have an impact on these physiological changes and pose the subject at risk of suffering adverse events from scuba diving. Arterial hypertension may be aggravated by underwater exercise and immersion. Symptomatic coronary artery disease and symptomatic heart rhythm disorders preclude diving. The occurrence of ventricular extrasystoles according to Lown classes I and II, and the presence of atrial fibrillation are considered relative contraindications in the absence of an aggravation following exercise. Asymptomatic subjects with Wolff-Parkinson-White syndrome may be allowed to dive, but in case of paroxysmal supraventricular tachycardia they must refrain from diving. Pacemakers will fail with increasing pressure, but some manufacturers have proven their products safe for pressure equivalents of up to 30 m of seawater, so that patients may dive uneventfully when staying within the 0-20 m depth range. Significant aortic or mitral valve stenosis will preclude diving, whereas regurgitation only will not be a problem. Right-to-left shunts have increasingly gained attention in diving medicine, since they may allow venous gas microbubbles to spill over to the arterial side of the circulation enabling the possibility of arterial gas embolism. Significant shunts thus preclude diving. The highly prevalent patent foramen ovale is considered a relative contraindication only when following certain recommendations for safe diving (Table 2). Metabolic disorders are of concern, since adiposity is associated with both, higher bubble grades in Doppler ultrasound detection after scuba dives when compared to normal subjects, and an increased epidemiologic risk of suffering from decompression illness. In conclusion, cardiovascular aspects are important in the assessment of fitness to dive, and certain cardiovascular conditions preclude scuba diving. Any history of cardiac disease or abnormalities detected during the routine medical examination should prompt to further evaluation and specialist referral.
Descriptors
Coronary Artery Disease/etiology/physiopathology, Decompression Sickness/etiology/physiopathology, Diving/adverse effects, Humans, Hypertension/etiology/physiopathology, Physical Fitness, Risk Assessment/methods, Risk Factors, Venous Thrombosis/etiology/physiopathology
Links
Book Title
Database
Publisher
Data Source
Authors
Muth,C. M., Tetzlaff,K.
Original/Translated Title
Tauchen und Herz. Kardiologische Aspekte des Sporttauchens
URL
Date of Electronic
PMCID
Editors
Effect of a fluoridated etchant on the shear bond strength of a composite resin to enamel 1992 Department of Pediatric Dentistry, University of Texas.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children
Periodical, Abbrev.
Int.J.Paediatr.Dent.
Pub Date Free Form
Apr
Volume
2
Issue
1
Start Page
25
Other Pages
30
Notes
LR: 20121115; JID: 9107511; 0 (Composite Resins); 0 (Fluorides, Topical); 0 (Phosphoric Acids); E4GA8884NN (phosphoric acid); ppublish
Place of Publication
ENGLAND
ISSN/ISBN
0960-7439; 0960-7439
Accession Number
PMID: 1525128
Language
eng
SubFile
Clinical Trial; Journal Article; Randomized Controlled Trial; D
DOI
Output Language
Unknown(0)
PMID
1525128
Abstract
The purpose of this study was to evaluate the effect of a fluoridated etching gel on the shear bond strength of a composite resin to enamel. A total of 75 extracted human permanent molars were used. A flat enamel surface was obtained with 600-grit silicon carbide paper and cleaned with a rubber cup and a water slurry of fine flour of pumice. The teeth were randomly distributed into 5 groups of 15 teeth each and etched as follows: group 1: 37% non-fluoridated phosphoric acid gel (Coe) for 60 seconds (control); group 2: 60% phosphoric acid gel with 0.5% NaF (Orthoprep) for 5 seconds; group 3: Orthoprep for 15 seconds; group 4: Orthoprep for 30 seconds; group 5: Orthoprep for 60 seconds. After etching, rinsing and drying, an unfilled resin (Coe Bond) was thinly applied with a brush and cured for 30 seconds. A nylon ring was placed over the area and filled with a light-cured composite resin (Occlusin). The teeth were thermocyled (100x), mounted in plastic cups and plaster, and sheared with a knife-edged blade in an Instron machine running at a crosshead speed of 1 mm/min. The results in MPa were as follows: group 1: 14.49 +/- 4.43; group 2: 10.81 +/- 3.70; group 3: 13.51 +/- 3.21; group 4: 14.79 +/- 3.76; group 5: 15.47 +/- 4.07. An analysis of variance showed that the results in groups 1, 4 and 5 were not significantly different but that the bond strengths in groups 2 and 3 were significantly lower. Fracture within the enamel occurred in 8 specimens in group 1, 5 in group 2, 6 in group 3, 8 in group 4, and 13 in group 5. In the fluoridated etchant groups the number of specimens showing enamel fracture increased as the application time of the etchant increased.
Descriptors
Acid Etching, Dental, Composite Resins, Dental Bonding, Dental Enamel, Fluorides, Topical, Humans, Phosphoric Acids, Tensile Strength
Links
Book Title
Database
Publisher
Data Source
Authors
Garcia-Godoy,F., Dodge,W. W., Donohue,M., O'Quinn,J. A.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Influence of smoking and snus on the prevalence and incidence of type 2 diabetes amongst men: the northern Sweden MONICA study 2004 Department of Medicine, Sunderby Hospital, Lulea, Sweden. mats.eliasson@nll.se
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of internal medicine
Periodical, Abbrev.
J.Intern.Med.
Pub Date Free Form
Aug
Volume
256
Issue
2
Start Page
101
Other Pages
110
Notes
LR: 20061115; JID: 8904841; CIN: J Intern Med. 2005 May;257(5):481-2; author reply 483. PMID: 15836667; ppublish
Place of Publication
England
ISSN/ISBN
0954-6820; 0954-6820
Accession Number
PMID: 15257722
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
10.1111/j.1365-2796.2004.01344.x [doi]
Output Language
Unknown(0)
PMID
15257722
Abstract
OBJECTIVE: To explore the effect of smoking and smokeless tobacco, 'snus', on the risk of type 2 diabetes. DESIGN: Population-based cross-sectional and prospective follow-up study in northern Sweden. SUBJECTS: A total of 3384 men, aged 25-74 years, who participated in the MONICA study in 1986, 1990, 1994 or 1999, 1170 of whom had an oral glucose tolerance test. In 1999, 1757 men from previous cohorts returned for re-examination. Main outcome measures. We compared the prevalence of type 2 diabetes or pathological glucose tolerance (PGT) amongst tobacco users to that of nonusers at entry into the study and at follow-up, using odds ratios. RESULTS: Compared with never users, the age-adjusted risk of prevalent clinically diagnosed diabetes for ever smokers was 1.88 (CI 1.17-3.0) and for smokers 1.74 (0.94-3.2). Corresponding odds ratios for snus users were 1.34 (0.65-2.7) and 1.18 (0.48-2.9). We found no increased risk of prevalent PGT in snus users or smokers. Former smokers and snus users had an insignificantly increased risk for PGT. Compared with nonusers, the age-adjusted risk of developing clinically diagnosed diabetes during follow-up was 4.63 (1.37-16) in consistent exclusive smokers, 3.20 (1.16-8.8) in ex-smokers and no cases in consistent snus users. The risk of PGT during follow-up was not increased in consistent tobacco users but evident, although not statistically significant, in those who quit snus during the follow-up period, 1.85 (0.60-5.7). Adjustment for physical activity and alcohol consumption did not change the major findings. CONCLUSIONS: The risk of diabetes for snus users was not significantly increased. Smoking was associated with prevalent and incident cases of diabetes. Ex-tobacco users tended towards more PGT.
Descriptors
Adult, Aged, Cross-Sectional Studies, Diabetes Mellitus, Type 2/epidemiology/etiology, Follow-Up Studies, Health Surveys, Humans, Incidence, Logistic Models, Male, Middle Aged, Prevalence, Risk, Smoking/adverse effects, Sweden/epidemiology, Tobacco, Smokeless/adverse effects
Links
Book Title
Database
Publisher
Data Source
Authors
Eliasson,M., Asplund,K., Nasic,S., Rodu,B.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Specialized intestinal metaplasia of the distal esophagus in gastroesophageal reflux disease: prevalence and clinico-demographic features 2003 Hospital de Clinicas, Universidade Federal do Parana. lrcaum7@bol.com.br
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Arquivos de Gastroenterologia
Periodical, Abbrev.
Arq.Gastroenterol.
Pub Date Free Form
Oct-Dec
Volume
40
Issue
4
Start Page
220
Other Pages
226
Notes
LR: 20061115; JID: 15310600R; 2004/05/31 [aheadofprint]; ppublish
Place of Publication
Brazil
ISSN/ISBN
0004-2803; 0004-2803
Accession Number
PMID: 15264043
Language
por
SubFile
English Abstract; Journal Article; IM
DOI
/S0004-28032003000400005 [doi]
Output Language
Unknown(0)
PMID
15264043
Abstract
BACKGROUND: Specialized intestinal metaplasia can be categorized according endoscopic and histological findings in long segment Barrett, short segment Barrett and specialized intestinal metaplasia of cardia. Barrett's esophagus is an acquired disease that is found in about 10%-13% of patients undergoing endoscopy for symptoms of gastroesophageal reflux disease and it is well established as predisposing to esophageal adenocarcinoma. The columnar epithelium with goblet cells replaces the normal squamous epithelium. OBJECTIVE: To determine the prevalence and clinical-demographic characteristics of specialized intestinal metaplasia of distal esophagus in the gastroesophageal reflux disease. METHODS: From April to October 2002, 402 patients referred to upper endoscopy due gastroesophageal reflux disease were evaluated through of a symptom questionnaire about clinical and demographic features and submitted to upper endoscopy with four-quadrant biopsies 1 cm below escamocolumnar junction. RESULTS: Eighteen point four percent of patients had specialized intestinal metaplasia, 0.5% long segment Barrett esophagus, 3.2% short segment Barrett's esophagus and 14.7% specialized intestinal metaplasia of cardia. Patients with Barrett's esophagus showed a tendency to be male and specialized metaplasia of cardia to be female. All patients with Barrett's esophagus were white. There was not association between symptoms of gastroesophageal reflux disease and specialized intestinal metaplasia, but patients with Barrett's esophagus showed a tendency to have symptoms over 5 years and had more hiatal hernia and esophagitis. The use of alcohol and tobacco was not related to the presence of specialized intestinal metaplasia. CONCLUSIONS: Barrett's esophagus was more related to the male gender, gastroesophageal reflux disease symptoms for 5 years or longer, more intense esophagitis and hiatal hernia, but was not related to the use of tobacco and alcohol.
Descriptors
Adolescent, Aged, Aged, 80 and over, Barrett Esophagus/epidemiology/pathology, Brazil/epidemiology, Cardia/pathology, Female, Gastroesophageal Reflux/physiopathology, Humans, Intestinal Diseases/epidemiology/pathology, Male, Metaplasia/epidemiology, Middle Aged, Prevalence, Prospective Studies, Stomach Diseases/epidemiology/pathology
Links
Book Title
Database
Publisher
Data Source
Authors
Caum,L. C., Bizinelli,S. L., Pisani,J. C., Amarantes,H. M., Ioshii,S. O., Carmes,E. R.
Original/Translated Title
Metaplasia intestinal especializada de esofago distal na doenca do refluxo gastroesofagico: prevalencia e aspectos clinico-epidemiologicos
URL
Date of Electronic
20040531
PMCID
Editors
Biofilm production and antifungal susceptibility patterns of Candida species 2004 Dokuz Eylul Universitesi Tip Fakultesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Izmir.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Mikrobiyoloji bulteni
Periodical, Abbrev.
Mikrobiyol.Bul.
Pub Date Free Form
Jan-Apr
Volume
38
Issue
2-Jan
Start Page
91
Other Pages
98
Notes
LR: 20131121; JID: 7503830; 0 (Antifungal Agents); 0 (Virulence Factors); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); ppublish
Place of Publication
Turkey
ISSN/ISBN
0374-9096; 0374-9096
Accession Number
PMID: 15293907
Language
tur
SubFile
English Abstract; Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
15293907
Abstract
In this study, biofilm production and antifungal susceptibility of various Candida species were examined and compared. A total number of 156 Candida species (94 C. albicans, 21 C. tropicalis, 18 C. glabrata, 12 C. parapsilosis, 9 C. krusei, 1 C. guilliermondii and 1 C. kefyr) isolated from different clinical specimens were included in the study. The biofilm production of the strains was searched by modified tube adherence and microplate methods. Their antifungal susceptibilities against fluconazole and amphotericin B were determined by microdilution method, according to NCCLS M27-A2 standards. Forty three (27.6%) and 26 (16.7%) of the strains were found to be slime producing by tube adherence and microplate methods, respectively. The agreement between the two methods were detected as 65 percent. The rate of biofilm formation by different species ranged between 17% and 55% by tube adherence test and 0 and 48% by microplate method. No significant difference was found between the biofilm production of C. albicans and non-albicans species by tube adherence test (p=0.29). However; a statistically important difference was found when microplate method was considered (p=0.04). MIC50 and MIC90 values for fluconazole ranged between 4-64 microg/ml and 32-->64 microg/ml for different Candida species while these values changed between 0.25-1 microg/ml and 0.5-2 microg/ml for amphotericin B, respectively. Forty-five (28.8%) and 23 (14.7%) of the isolates were found to be dose dependent susceptible and resistant to fluconazole, respectively. Eleven (6.7%) of the strains had MIC values >1 microg/ml for amphotericin B. When the relation between the biofilm production and the susceptibility categories of the strains for amphotericin B were searched, no statistical differences were found by any of the two methods (p=0.12 and p=0.50). A statistically important difference (p=0.03) was determined by tube adherence test and no important difference (p=0.11) was detected by microplate method when fluconazole susceptibility categories were considered. As a conclusion, it has been determined that biofilm production which is a potential virulence factor for Candida species seems to be in agreement with the antifungal susceptibility categories of the strains especially for amphotericin B when the planktonic cells were used for the susceptibility testing.
Descriptors
Amphotericin B/pharmacology, Antifungal Agents/pharmacology, Biofilms/growth & development, Candida/drug effects/pathogenicity, Dose-Response Relationship, Drug, Drug Resistance, Fungal, Fluconazole/pharmacology, Humans, Microbial Sensitivity Tests, Reproducibility of Results, Virulence Factors
Links
Book Title
Database
Publisher
Data Source
Authors
Yucesoy,M., Karaman,M.
Original/Translated Title
Candida turlerinin biyofilm uretimi ve antifungal duyarlilik paternleri
URL
Date of Electronic
PMCID
Editors
The Munich Barrett follow up study: suspicion of Barrett&#39;s oesophagus based on either endoscopy or histology only--what is the clinical significance? 2004 Central Interdisciplinary, Endoscopy Unit, Department of Gastroenterology, Campus Virchow, Charite University Hospitals, Berlin, Germany. Thomas.Roesch@charite.de
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Gut
Periodical, Abbrev.
Gut
Pub Date Free Form
Oct
Volume
53
Issue
10
Start Page
1402
Other Pages
1407
Notes
LR: 20140608; JID: 2985108R; OID: NLM: PMC1774245; ppublish
Place of Publication
England
ISSN/ISBN
0017-5749; 0017-5749
Accession Number
PMID: 15361485
Language
eng
SubFile
Journal Article; Multicenter Study; AIM; IM
DOI
10.1136/gut.2003.036822 [doi]
Output Language
Unknown(0)
PMID
15361485
Abstract
BACKGROUND: The incidence of distal oesophageal adenocarcinoma is rising, with chronic reflux and Barrett's oesophagus being considered risk factors. Reliable detection of Barrett's oesophagus during upper endoscopy is therefore mandatory but requires both endoscopy and histology for confirmation. Appropriate management of patients with endoscopic suspicion but negative on histology, or vice versa, or of patients with no endoscopic suspicion but with a biopsy diagnosis of intestinal metaplasia at the gastro-oesophageal junction, has not yet been studied prospectively. PATIENTS AND METHODS: In a prospective multicentre study, 929 patients (51% male, mean age 50 years) referred for upper gastrointestinal endoscopy were included; 59% had reflux symptoms. The endoscopic aspect of the Z line and any suspicion of Barrett's oesophagus were noted, and biopsies were taken in all patients from the Z line (n = 4), gastric cardia (n = 2), and body and antrum (n = 2 each). Biopsies positive for specialised intestinal metaplasia (SIM) were reviewed by a reference pathologist for a final Barrett's oesophagus diagnosis. All patients with endoscopic and/or histological suspicion of Barrett's oesophagus were invited for a follow up endoscopy; the remaining cases (no endoscopic or histological suspicion of Barrett's oesophagus) were followed clinically. RESULTS: Of 235 patients positive for Barrett's oesophagus on endoscopy and/or histology, 63% agreed to undergo repeat endoscopy (mean follow up period 30.5 months). 46% of patients with an endoscopic Barrett's oesophagus diagnosis but no histological confirmation (group A) showed the same distribution, a further 42% did not have Barrett's oesophagus, and 11% had confirmed Barrett's oesophagus on both endoscopy and biopsy on follow up. In the group with a histological Barrett's oesophagus diagnosis but negative on initial endoscopy (group B), follow up showed the same in 26% whereas 46% had no Barrett's oesophagus, and confirmed Barrett's oesophagus (endoscopy plus histology) was diagnosed in 17%. Of the study population, 16 patients had Barrett's oesophagus on initial endoscopy confirmed by histology which remained constant in 70% at follow up (group C). Of the remaining patients without an initial Barrett's oesophagus diagnosis on either endoscopy or histology (group D) and only clinical follow up (mean follow up period 38 months), one confirmed Barrett's oesophagus case was found among 100 patients re-endoscoped outside of the study protocol. However, no single case of dysplasia or cancer of the distal oesophagus was detected in any patient during the study period. CONCLUSIONS: Even in a specialised gastroenterology setting, reproducibility of presumptive endoscopic or histological diagnoses of Barrett's oesophagus at follow up were poor. Only 10-20% of cases with either endoscopic or histological suspicion of Barrett's oesophagus had established Barrett's oesophagus after 2.5 years of follow up. The risk of dysplasia in this population was very low and hence meticulous follow up may not be required.
Descriptors
Adolescent, Adult, Aged, Aged, 80 and over, Barrett Esophagus/diagnosis/pathology, Esophageal Neoplasms/diagnosis/pathology, Esophagoscopy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Patient Selection, Precancerous Conditions/diagnosis/pathology, Prognosis, Prospective Studies, Reproducibility of Results
Links
Book Title
Database
Publisher
Data Source
Authors
Meining,A., Ott,R., Becker,I., Hahn,S., Muhlen,J., Werner,M., Hofler,H., Classen,M., Heldwein,W., Rosch,T.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC1774245
Editors
Factors associated with age of smoking initiation in adult populations from different ethnic backgrounds 2004 The Cheryl Spencer Department of Nursing, Faculty of Social Welfare and Health Studies, University of Haifa, Israel. ornaepel@research.haifa.ac.il
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
European journal of public health
Periodical, Abbrev.
Eur.J.Public Health
Pub Date Free Form
Sep
Volume
14
Issue
3
Start Page
301
Other Pages
305
Notes
LR: 20071115; JID: 9204966; ppublish
Place of Publication
England
ISSN/ISBN
1101-1262; 1101-1262
Accession Number
PMID: 15369038
Language
eng
SubFile
Comparative Study; Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
15369038
Abstract
BACKGROUND: The age at which the individual begins smoking may influence the health of smokers at an older age. Cultural and social factors effect the age of smoking initiation. METHODS: A cross-sectional national survey of a random sample of 6,021 Israeli residents over the age of 21 were interviewed by telephone. The sample consisted of 4248 Jews, 858 Arabs and 915 immigrants, 856 of them were from the former Soviet Union. RESULTS: Compared to the Jewish population the Jews who immigrated from the former Soviet Union began smoking at an earlier age and the Arabs started smoking at an older age. The young respondents in all ethnic groups reported starting to smoke at a younger age compared to the older respondents, and there was a decrease in smoking initiation at an older age. Father smoking during childhood predicted earlier age of smoking initiation but not mother or sibling smoking, significantly among Jews and immigrants and non-significantly among Arabs. CONCLUSIONS: Age of smoking initiation is dependent on the ethnic background in which the smokers grow up, however, the influence of the father smoking seems to be similar in all population groups. It seems that a higher percentage of young adults started smoking at an early age and there is a decrease in smoking initiation at older ages in all ethnic groups.
Descriptors
Adult, Age Factors, Aged, Arabs, Cross-Sectional Studies, Emigration and Immigration, Ethnic Groups, Fathers, Female, Humans, Interviews as Topic, Israel/epidemiology, Jews, Logistic Models, Male, Middle Aged, Mothers, Odds Ratio, Sex Factors, Siblings, Smoking/epidemiology, USSR/ethnology
Links
Book Title
Database
Publisher
Data Source
Authors
Baron-Epel,O., Haviv-Messika,A.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Review article: management of oesophageal adenocarcinoma -- control of acid, bile and inflammation in intervention strategies for Barrett&#39;s oesophagus 2004 Digestion Diseases Centre, Royal Infirmary, Leicester, UK. j.jankowski@le.ac.uk
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Alimentary Pharmacology & Therapeutics
Periodical, Abbrev.
Aliment.Pharmacol.Ther.
Pub Date Free Form
Oct
Volume
20 Suppl 5
Issue
Start Page
71
Other Pages
80; discussion 95-6
Notes
LR: 20061115; JID: 8707234; 0 (Gastrointestinal Agents); RF: 82; ppublish
Place of Publication
England
ISSN/ISBN
0269-2813; 0269-2813
Accession Number
PMID: 15456468
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; Review; IM
DOI
10.1111/j.1365-2036.2004.02143.x [doi]
Output Language
Unknown(0)
PMID
15456468
Abstract
Oesophagitis is associated with Barrett's metaplasia in about 10% of individuals. The UK has one of the highest world-wide prevalences of Barrett's metaplasia, with 1% of adults having the condition, resulting in an incidence of oesophageal adenocarcinoma two to three times that seen in either Europe or North America. In addition, the conversion rate to cancer in individuals with Barrett's metaplasia in UK surveillance programmes is twice that observed in the USA (0.96% per year vs. 0.4% per year), lending further support to the notion that the UK is a high-risk region. The evidence base on what can be achieved with medical therapy to reduce the risk of dysplasia or the development of adenocarcinoma needs to be strengthened with data from randomized controlled trials, as existing data have many limitations. Patients with Barrett's metaplasia respond variably to proton pump inhibitor therapy (even high-dose therapy 'normalizes' acid reflux in only 85% of cases), and symptom control is a poor determinant of the adequacy of suppression of acid reflux. Gastro-oesophageal reflux is implicated in the pathogenesis of Barrett's metaplasia, and ex vivo and in vitro evidence suggests that its attenuation reverses proliferation and biological variables over days, and perhaps the metaplastic histology to a degree over years. The effect of proton pump inhibitor therapy on cancer risk in the long term is essentially unknown. Acid suppressant therapy or anti-reflux surgery on its own does not result in the complete regression of the metaplastic epithelium. Bile acids, present especially frequently in the refluxate of Barrett's oesophagus patients, are also likely to influence the development and persistence of metaplasia. Barrett's metaplasia is replaced by a squamous epithelium when acid reflux is well controlled and the epithelium is physically destroyed by ablation with argon plasma coagulation or photodynamic therapy. These modalities are invasive and are not likely to be useful in the routine management of patients with Barrett's oesophagus without dysplasia or cancer. Why metaplasia does not fully regress once external initiating stimuli are removed is a mystery. There is some evidence to implicate a variety of molecules, including cyclo-oxygenase-2, tumour necrosis factor-alpha, beta-catenin nuclear translocation and mitogen-activated protein kinase signalling, because they are expressed preferentially in metaplastic rather than normal or inflamed squamous oesophageal mucosa. The use of non-steroidal anti-inflammatory drugs, including aspirin, is associated with a decreased incidence of oesophageal adenocarcinoma. There is therefore a great need for randomized controlled trials to assess the outcomes of such chemopreventive therapy in patients with Barrett's metaplasia.
Descriptors
Barrett Esophagus/prevention & control, Bile/secretion, Chemoprevention/methods, Drug Costs, Esophageal Neoplasms/prevention & control, Esophagitis/prevention & control, Gastroesophageal Reflux/prevention & control, Gastrointestinal Agents/therapeutic use, Humans, Risk Factors
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Authors
Jankowski,J. A., Anderson,M.
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