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Negative effects of passive smoking on the (unborn) child 2002 Erasmus Medisch Centrum, Sophia Kinderziekenhuis, afd. Longziekten, Postbus 2060, 3000 CB Rotterdam.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Nederlands tijdschrift voor geneeskunde
Periodical, Abbrev.
Ned.Tijdschr.Geneeskd.
Pub Date Free Form
23-Feb
Volume
146
Issue
8
Start Page
356
Other Pages
359
Notes
LR: 20061115; JID: 0400770; 0 (Tobacco Smoke Pollution); CIN: Ned Tijdschr Geneeskd. 2002 Apr 20;146(16):782-3; author reply 783. PMID: 11998360; CIN: Ned Tijdschr Geneeskd. 2002 Apr 20;146(16):782; author reply 782. PMID: 11998361; ppublish
Place of Publication
Netherlands
ISSN/ISBN
0028-2162; 0028-2162
Accession Number
PMID: 11887620
Language
dut
SubFile
English Abstract; Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
11887620
Abstract
The negative effects of passive smoking on the health of the foetus or child continue to receive little attention, despite the large volume of research in this area. Passive smoking during pregnancy is associated with low birth weight, a reduction in head circumference at birth, and a far higher incidence of sudden infant death syndrome. Exposure to cigarette smoke also leads to a decreased lung function, an increased risk of severe infections, including respiratory syncytial virus bronchiolitis, meningococcal disease and middle ear infections. There is no association between passive smoking and the development of allergic asthma, but passive smoking does cause an increase in the prevalence of respiratory symptoms in children with or without asthma. Finally, there is a relation between passive smoking and behavioural disorders including attention deficit/hyperactivity disorder (ADHD). Passive smoking before birth seems even more harmful than after birth. A causal relationship is suggested in most studies, or has been proven by animal experiments. A decreased birth weight in general increases the risk of developing chronic diseases as an adult, such as hypertension, cardiovascular disease and type 2 diabetes mellitus. This extensive knowledge about the adverse health effects of smoke exposure in (unborn) children deserves greater attention in the counselling of pregnant women, and in anti-smoking campaigns.
Descriptors
Attention Deficit Disorder with Hyperactivity/etiology, Communicable Diseases/etiology, Female, Humans, Infant, Low Birth Weight/physiology, Infant, Newborn, Lung Diseases/etiology, Pregnancy, Prenatal Exposure Delayed Effects, Respiratory Distress Syndrome, Newborn/etiology, Sudden Infant Death/etiology, Tobacco Smoke Pollution/adverse effects
Links
Book Title
Database
Publisher
Data Source
Authors
Hofhuis,W., Merkus,P. J., de Jongste,J. C.
Original/Translated Title
Nadelige effecten van passief roken op het (ongeboren) kind
URL
Date of Electronic
PMCID
Editors
Efficacy of resident training in smoking cessation: a randomized, controlled trial of a program based on application of behavioral theory and practice with standardized patients 2002 Lausanne University Outpatient Clinic and Institute of Social and Preventive Medicine, Lausanne, Switzerland. Jacques.Cornuz@chuv.hospvd.ch
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Annals of Internal Medicine
Periodical, Abbrev.
Ann.Intern.Med.
Pub Date Free Form
19-Mar
Volume
136
Issue
6
Start Page
429
Other Pages
437
Notes
LR: 20061115; JID: 0372351; ppublish
Place of Publication
United States
ISSN/ISBN
1539-3704; 0003-4819
Accession Number
PMID: 11900495
Language
eng
SubFile
Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; AIM; IM
DOI
200203190-00006 [pii]
Output Language
Unknown(0)
PMID
11900495
Abstract
BACKGROUND: New educational programs must be developed to improve physicians' skills and effectiveness in counseling patients about smoking cessation. OBJECTIVE: To assess the efficacy of an educational program based on behavioral theory, active learning methods, and practice with standardized patients in helping patients abstain from smoking and changing physicians' counseling practices. DESIGN: Cluster randomized, controlled trial. SETTING: Two general internal medicine clinics in Switzerland. PARTICIPANTS: 35 residents and 251 consecutive smoking patients. INTERVENTION: A training program administered over two half-days, during which physicians learned to provide counseling that matched smokers' motivation to quit and practiced these skills with standardized patients acting as smokers at different stages of change. The control intervention was a didactic session on management of dyslipidemia. MEASUREMENTS: Self-reported abstinence from smoking at 1 year of follow-up, which was validated by exhaled carbon monoxide testing at one clinic; score of overall quality of counseling based on use of 14 counseling strategies; patient willingness to quit; and daily cigarette consumption. RESULTS: At 1 year of follow-up, abstinence from smoking was significantly higher in the intervention group than in the control group (13% vs. 5%; P = 0.005); this corresponded to a cluster-adjusted odds ratio of 2.8 (95% CI, 1.4 to 5.5). Residents who received the study training provided better counseling than did those who received the control training (mean score, 4.0 vs. 2.7; P = 0.002). Smokers' willingness to quit was also higher in the intervention group (94% vs. 80%; P = 0.007). A nonsignificant trend toward lower daily cigarette consumption in the intervention group was observed. CONCLUSION: A training program in smoking cessation administered to physicians that was based on behavioral theory and practice with standardized patients significantly increased the quality of physicians' counseling, smokers' motivation to quit, and rates of abstinence from smoking at 1 year.
Descriptors
Adolescent, Adult, Aged, Behavior Therapy, Clinical Competence, Counseling/methods, Double-Blind Method, Family Practice/education, Female, Follow-Up Studies, Humans, Hyperlipidemias/prevention & control, Internal Medicine/education, Internship and Residency, Male, Motivation, Smoking Cessation/methods/psychology
Links
Book Title
Database
Publisher
Data Source
Authors
Cornuz,J., Humair,J. P., Seematter,L., Stoianov,R., van Melle,G., Stalder,H., Pecoud,A.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Youth tobacco surveillance--United States, 2000 2001
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
MMWR.CDC surveillance summaries : Morbidity and mortality weekly report.CDC surveillance summaries / Centers for Disease Control
Periodical, Abbrev.
MMWR CDC Surveill.Summ.
Pub Date Free Form
2-Nov
Volume
50
Issue
4
Start Page
1
Other Pages
84
Notes
LR: 20120329; JID: 8407977; 0 (Tobacco Smoke Pollution); EIN: MMWR CDC Surveill Summ 2001 Nov 23;50(46):1036; ppublish
Place of Publication
United States
ISSN/ISBN
Accession Number
PMID: 11902401
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
11902401
Abstract
PROBLEM/CONDITION: Tobacco use is the single leading preventable cause of death in the United States, accounting for approximately 430,000 deaths each year. The prevalence of cigarette smoking nationwide among high school students increased during the 1990s, peaking during 1996-1997, then began a gradual decline. Approximately 80% of tobacco users initiate use before age 18 years. If the trend in early initiation of cigarette smoking continues, approximately 5 million children aged <18 years who are living today will die prematurely because they began to smoke cigarettes during adolescence. The economic costs associated with tobacco use ranges from $53 billion to $73 billion per year in medical expenses and $47 billion in lost productivity. Because of these health and economic consequences, CDC has recommended that states establish and maintain comprehensive tobacco-control programs to reduce tobacco use among youth. REPORTING PERIOD: January 2000 through December 2000. DESCRIPTION OF THE SYSTEM: To assist states in developing and maintaining their state-based comprehensive tobacco prevention and control programs, CDC developed the Youth Tobacco Surveillance and Evaluation System, which includes international, national, and state school-based surveys of middle school and high school students. Two components of this system are discussed in this report--the National Youth Tobacco Survey and the state Youth Tobacco Surveys. The national survey is representative of students in the 50 states and the District of Columbia; 35,828 students in 324 schools completed questionnaires in the spring of 2000. Twenty-nine state surveys were conducted in the spring and fall of 2000; state sample sizes ranged from 583 to 33,586 students. This report summarizes data from the 2000 national survey and state surveys. RESULTS AND INTERPRETATION: Findings from the National Youth Tobacco Survey indicate that current tobacco use ranges from 15.1% among middle school students to 34.5% among high school students. Cigarette smoking is the most prevalent form of tobacco use, followed by cigar smoking and smokeless tobacco use. Approximately one half of current cigarette smokers in middle school and high school report that they usually smoke Marlboro cigarettes. Black students are more likely to smoke Newport cigarettes than any other brand. More than one half of current cigarette smokers in middle school and high school report that they want to stop smoking. Nearly one fourth of middle school and high school students who have never smoked cigarettes are susceptible to initiating cigarette smoking in the next year. Exposure to secondhand smoke (e.g., environmental tobacco smoke) is substantially higher among both middle school and high school students. During the week before the survey, approximately 9 out of 10 current cigarette smokers and one half of never cigarette smokers were in the same room with someone who was smoking cigarettes; and 8 out of 10 current cigarette smokers and 3 out of 10 never cigarette smokers rode in a car with someone who was smoking cigarettes. Approximately 70% of middle school and 57% of high school students who currently smoke cigarettes live in a home where someone smokes cigarettes. Among never cigarette smokers, approximately 3 out of 10 live in a home where someone smokes cigarettes. Approximately 69% of middle school and 58% of high school students aged <18 years who currently smoke cigarettes were not asked to show proof of age when they bought or tried to buy cigarettes. Approximately 8 out of 10 middle school and high school students have seen antismoking commercials. Eight out of 10 middle school students report having seen actors using tobacco on television or in the movies, and approximately 11% of middle school and 16% of high school students who had never used tobacco would wear or use something with a tobacco company name or picture on it. This rate increases to nearly 60% for current tobacco users. PUBLIC
Descriptors
Adolescent, Advertising as Topic, Attitude, Child, Humans, Population Surveillance, Prevalence, Schools, Smoking/epidemiology/prevention & control/psychology, Smoking Cessation, Tobacco Smoke Pollution, United States/epidemiology
Links
Book Title
Database
Publisher
Data Source
Authors
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Tobacco smoking habits, beliefs, and attitudes among medical students in Tirana, Albania 2002 Respiratory Pathophysiology, Sauk University Clinics, Tirana, Albania.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Preventive medicine
Periodical, Abbrev.
Prev.Med.
Pub Date Free Form
Mar
Volume
34
Issue
3
Start Page
370
Other Pages
373
Notes
LR: 20041117; CI: (C)2002; JID: 0322116; ppublish
Place of Publication
United States
ISSN/ISBN
0091-7435; 0091-7435
Accession Number
PMID: 11902854
Language
eng
SubFile
Journal Article; IM
DOI
10.1006/pmed.2001.0994 [doi]
Output Language
Unknown(0)
PMID
11902854
Abstract
BACKGROUND: Many surveys throughout the world have evaluated the smoking behaviors, beliefs, and attitudes of medical students, but no information is available from Albania. METHOD: A cross-sectional survey in classroom settings using a self-administered questionnaire was performed at the University of Tirana during October 2000. RESULTS: In the first and fifth years of medical school, 149 (68.5% women) and 185 (55% women) students, respectively, completed the questionnaire, with overall response rates of 82 and 92%. Tobacco smoking prevailed among males. The smoking rates among first-year medical students were 34% among men and 5% among women. Among fifth-year students, 55% of the men and 34% of the women smoked. The percentages of occasional smokers were 29 and 49%, respectively, among the first- and fifth-year students who smoked. Most medical students reported knowing the health hazards of tobacco. Most students in both groups believed that smoking should be restricted in hospitals. Slightly more than half of the students stated that they will regularly advise smokers against smoking in their future jobs. CONCLUSION: Tobacco smoking is common among medical students in Albania. Targeted antismoking training should be mandatory for medical students in Albania.
Descriptors
Adult, Albania/epidemiology, Attitude to Health, Cross-Sectional Studies, Data Collection, Female, Health Behavior, Health Knowledge, Attitudes, Practice, Humans, Male, Prevalence, Probability, Reference Values, Risk Assessment, Sex Distribution, Smoking/epidemiology/psychology, Students, Medical, Urban Population
Links
Book Title
Database
Publisher
American Health Foundation and Elsevier Science (USA)
Data Source
Authors
Vakeflliu,Y., Argjiri,D., Peposhi,I., Agron,S., Melani,A. S.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Measurement-specific quality-of-life satisfaction during the menopause in an Arabian Gulf country 2000 Department of Community Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Climacteric : the journal of the International Menopause Society
Periodical, Abbrev.
Climacteric
Pub Date Free Form
Mar
Volume
3
Issue
1
Start Page
43
Other Pages
49
Notes
LR: 20151119; JID: 9810959; ppublish
Place of Publication
United States
ISSN/ISBN
1369-7137; 1369-7137
Accession Number
PMID: 11910609
Language
eng
SubFile
Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
11910609
Abstract
OBJECTIVE: The aim of this study was to use an instrument, the menopause-specific quality-of-life satisfaction questionnaire for the postmenopausal period, in the United Arab Emirates (UAE). DESIGN: A cross-sectional descriptive study was used to generate menopause symptoms experienced by Arabian Gulf women. Measurement-specific quality-of-life satisfaction questionnaires were used and face-to-face interviews were performed. SETTING: The study was based in primary health-care clinics in Al Ain City, Sharjah and Dubai Emirates, UAE. SUBJECTS: A multistage sampling design was used, and a representative sample of 450 UAE females aged 45 years and above were included during January-April 1999. RESULTS: Of the 450 women living in both urban and rural areas, 390 women agreed to participate (86.7%) and responded to the study. The mean age and standard deviation (SD) of the subjects was 56.5 +/- 6.6 years, and the median age of natural menopause in the present study was 48 years (mean +/- SD 48.4 +/- 3.8). The rate of consanguinous marriages in the sample was found to be 47.2%. The most common disease was found to be diabetes mellitus (10.3%), followed by osteoarthritis (7.7%), hypertension (7.2%) and asthma (6.2%), but the majority of subjects (68.7%) had no specific disease. Out of 29 possible symptoms, the mean number of symptoms was 7.57 (range 0-24). The most frequent symptom was 'aches in the back of the neck or head' at 46.4% followed by 'aches in the muscles/joints' at 34.6%. The least reported symptom was 'facial hair' at 15.9%. Increasing education resulted in more symptoms reported, and increasing parity resulted in fewer symptoms reported. In the present study, it was found that employed women experienced more symptoms and disorders. Of the total sample, 28.5% of the subjects reported no symptoms. In the four domains, 69% reported physical symptoms, 58.7% reported psychosocial symptoms, 40% reported vasomotor symptoms and 37.9% reported sexual symptoms. Spearman's rank correlation coefficient indicated that there is highly statistically significant concordance between the four domains (p < 0.01). CONCLUSION: The present study showed that menopause-related symptoms in UAE women are fewer and of less severity than in Western women. The postmenopausal women, despite a continued decline in estrogen levels, reported few symptoms as part of a normal life stage, suggesting that they were able to cope with stress.
Descriptors
Asthma/epidemiology, Consanguinity, Diabetes Mellitus/epidemiology, Educational Status, Female, Headache/epidemiology, Hot Flashes, Humans, Hypertension/epidemiology, Joints, Libido, Menopause, Middle Aged, Neck, Osteoarthritis/epidemiology, Pain/epidemiology, Parity, Quality of Life, Rural Population, Sexual Dysfunction, Physiological/epidemiology, Surveys and Questionnaires, Sweating, United Arab Emirates/epidemiology, Urban Population
Links
Book Title
Database
Publisher
Data Source
Authors
Bener,A., Rizk,D. E., Shaheen,H., Micallef,R., Osman,N., Dunn,E. V.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Diversity, dynamics, and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis 2002 Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, 6703 CT Wageningen, The Netherlands.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Applied and Environmental Microbiology
Periodical, Abbrev.
Appl.Environ.Microbiol.
Pub Date Free Form
Apr
Volume
68
Issue
4
Start Page
1882
Other Pages
1892
Notes
LR: 20140612; JID: 7605801; 0 (DNA, Bacterial); 0 (RNA, Ribosomal, 16S); OID: NLM: PMC123848; ppublish
Place of Publication
United States
ISSN/ISBN
0099-2240; 0099-2240
Accession Number
PMID: 11916708
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; IM
DOI
Output Language
Unknown(0)
PMID
11916708
Abstract
The diversity and dynamics of the microbial communities during the manufacturing of Ragusano cheese, an artisanal cheese produced in Sicily (Italy), were investigated by a combination of classical and culture-independent approaches. The latter included PCR, reverse transcriptase-PCR (RT-PCR), and denaturing gradient gel electrophoresis (DGGE) of 16S rRNA genes (rDNA). Bacterial and Lactobacillus group-specific primers were used to amplify the V6 to V8 and V1 to V3 regions of the 16S rRNA gene, respectively. DGGE profiles from samples taken during cheese production indicated dramatic shifts in the microbial community structure. Cloning and sequencing of rDNA amplicons revealed that mesophilic lactic acid bacteria (LAB), including species of Leuconostoc, Lactococcus lactis, and Macrococcus caseolyticus were dominant in the raw milk, while Streptococcus thermophilus prevailed during lactic fermentation. Other thermophilic LAB, especially Lactobacillus delbrueckii and Lactobacillus fermentum, also flourished during ripening. Comparison of the rRNA-derived patterns obtained by RT-PCR to the rDNA DGGE patterns indicated a substantially different degree of metabolic activity for the microbial groups detected. Identification of cultivated LAB isolates by phenotypic characterization and 16S rDNA analysis indicated a variety of species, reflecting to a large extent the results obtained from the 16S rDNA clone libraries, with the significant exception of the Lactobacillus delbrueckii species, which dominated in the ripening cheese but was not detected by cultivation. The present molecular approaches combined with culture can effectively describe the complex ecosystem of natural fermented dairy products, giving useful information for starter culture design and preservation of artisanal fermented food technology.
Descriptors
Cheese/microbiology, Colony Count, Microbial, DNA, Bacterial/analysis, Ecosystem, Electrophoresis, Polyacrylamide Gel/methods, Genetic Variation, Gram-Positive Bacteria/classification/genetics/isolation & purification, Lactobacillus, Leuconostoc, Polymerase Chain Reaction, RNA, Ribosomal, 16S/genetics, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA
Links
Book Title
Database
Publisher
Data Source
Authors
Randazzo,C. L., Torriani,S., Akkermans,A. D., de Vos,W. M., Vaughan,E. E.
Original/Translated Title
URL
Date of Electronic
PMCID
PMC123848
Editors
Real-time measurement of indoor particulate matter originating from environmental tobacco smoke: a pilot study 2002 Istituto senza fumo, Istituto nazionale per lo studio e la cura dei tumori, Milano. giovanni.invernizzi@novanet.it
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Epidemiologia e prevenzione
Periodical, Abbrev.
Epidemiol.Prev.
Pub Date Free Form
Jan-Feb
Volume
26
Issue
1
Start Page
30
Other Pages
34
Notes
LR: 20061115; JID: 8902507; 0 (Tobacco Smoke Pollution); ppublish
Place of Publication
Italy
ISSN/ISBN
1120-9763; 1120-9763
Accession Number
PMID: 11942144
Language
ita
SubFile
Comparative Study; English Abstract; Journal Article; IM
DOI
Output Language
Unknown(0)
PMID
11942144
Abstract
Short-term measurement of suspended particulate matter has been recently made possible since the release of laser-operating portable instruments. Data of a pilot study of field evaluation of environmental tobacco smoke (ETS) with a portable instrument are reported. We analysed the concentrations of total suspended particle (TSP) and of the fine particles PM10, PM7, PM2.5 and PM1 released indoor from a single cigarette, and their levels inside smoking- and non-smoking-areas of a restaurant. The results indicate that ETS creates high level indoor particulate pollution, with concentrations of PM10 exceeding air quality standards. This kind of field evaluation could allow a more careful assessing of short-term exposure to ETS and its relevance to public health.
Descriptors
Air Pollution, Indoor/analysis, Humans, Pilot Projects, Public Health, Time Factors, Tobacco Smoke Pollution/analysis
Links
Book Title
Database
Publisher
Data Source
Authors
Invernizzi,G., Ruprecht,A., Mazza,R., Majno,E., Rossetti,E., Paredi,P., Boffi,R.
Original/Translated Title
La misurazione in tempo reale del particolato fine prodotto da fumo di sigaretta negli ambienti indoor: risultati di uno studio pilota
URL
Date of Electronic
PMCID
Editors
Longitudinal association between plaque and gingival bleeding in smokers and non-smokers 2002 School of Dental Medicine, University of Heidelberg, Germany. perio@t-online.de
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Journal of clinical periodontology
Periodical, Abbrev.
J.Clin.Periodontol.
Pub Date Free Form
Apr
Volume
29
Issue
4
Start Page
287
Other Pages
294
Notes
LR: 20071115; JID: 0425123; ppublish
Place of Publication
Denmark
ISSN/ISBN
0303-6979; 0303-6979
Accession Number
PMID: 11966925
Language
eng
SubFile
Journal Article; Research Support, Non-U.S. Gov't; D; IM
DOI
cpe290403 [pii]
Output Language
Unknown(0)
PMID
11966925
Abstract
BACKGROUND/AIMS: Whereas accumulation of dentogingival plaque inevitably leads to inflammatory reactions in the adjacent gingival tissue, there is limited information with regard to factors influencing naturally occurring fluctuation between gingival health and disease. The major aims of the present study were to investigate site-specific associations between plaque and gingivitis as well as transition dynamics of naturally occurring gingivitis in smoking and non-smoking young adults. METHODS: 65 systemically healthy young adults, 19 to 30 years old, participated. 33 volunteers smoked at least 20 cigarettes per day, whereas 32 subjects were non-smokers. Clinical periodontal conditions were assessed four times within a time period of 6 months. An ecological approach in data analysis as well as site-specific analyses considering the correlated structure of data were performed. RESULTS: At the outset and after 6 months, smokers had significantly more supragingival plaque than non-smokers. At the final examination, bleeding upon probing as well as calculus were more prevalent in smokers. A site-by-site analysis revealed that smokers tended to have a weaker association between supragingival plaque and bleeding on probing than non-smokers (median Mantel-Haenszel's common odds ratio 1.91 vs. 2.89, p=0.07). Multiple logistic regression analyses adjusted for periodontal probing depth, plaque and calculus identified smoking status to significantly increase the risk for the first transition of non-bleeding to bleeding upon probing by 86% (p<0.01). In contrast, recovery of bleeding sites was positively influenced by female gender, but not smoking. CONCLUSIONS: In multivariate analyses adjusted for probing depth, plaque and calculus, smokers appeared to be at higher risk for the transition from non-bleeding to bleeding on probing. Weaker associations between plaque and naturally occurring gingivitis in smokers may have important consequences for preventive strategies for gingivitis.
Descriptors
Adult, Analysis of Variance, Dental Calculus/etiology, Dental Devices, Home Care, Dental Plaque/etiology, Disease Progression, Female, Follow-Up Studies, Gingival Hemorrhage/etiology, Gingival Recession/etiology, Gingivitis/etiology, Humans, Logistic Models, Longitudinal Studies, Male, Multivariate Analysis, Odds Ratio, Periodontal Attachment Loss/etiology, Periodontal Pocket/etiology, Reproducibility of Results, Risk Factors, Sex Factors, Smoking/adverse effects, Statistics as Topic, Statistics, Nonparametric, Toothbrushing
Links
Book Title
Database
Publisher
Data Source
Authors
Muller,H. P., Stadermann,S., Heinecke,A.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Recurrent inner ear decompression sickness associated with a patent foramen ovale 2002 Department of Ear, Nose, and Throat Surgery (HNO), University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. christoph_klingmann@med.uni-heidelberg.de
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Archives of Otolaryngology--Head & Neck Surgery
Periodical, Abbrev.
Arch.Otolaryngol.Head.Neck.Surg.
Pub Date Free Form
May
Volume
128
Issue
5
Start Page
586
Other Pages
588
Notes
LR: 20060328; JID: 8603209; ppublish
Place of Publication
United States
ISSN/ISBN
0886-4470; 0886-4470
Accession Number
PMID: 12003593
Language
eng
SubFile
Case Reports; Journal Article; AIM; IM
DOI
ocn10516 [pii]
Output Language
Unknown(0)
PMID
12003593
Abstract
Isolated inner ear injuries occurring during shallow scuba dives are an uncommon manifestation of decompression sickness in recreational divers. We describe a patient who presented with the typical symptoms of inner ear involvement after 2 independent dives within the decompression limits. The diver reported symptoms of unilateral (right-sided) hearing loss, tinnitus, and vertigo after dives to 35 and 50 m. After treatment with hyperbaric oxygen, his symptoms completely resolved. To confirm the hypothesis of inner ear decompression sickness (IEDCS), we examined the patient for a right-to-left shunt by cranial Doppler ultrasound and found a patent foramen ovale. The existence of a patent foramen ovale is suspected to be a risk factor for developing neurological symptoms of decompression sickness. There was no evidence of any other risk factors, so we suggest that the relevant right-to-left shunt in our patient may have been the predisposing factor that caused the inner ear symptoms during his scuba dive.
Descriptors
Adult, Barotrauma/complications/diagnosis/therapy, Diving/injuries, Ear, Inner/injuries, Heart Septal Defects, Atrial/complications/ultrasonography, Humans, Hyperbaric Oxygenation, Male, Risk Factors, Ultrasonography, Doppler
Links
Book Title
Database
Publisher
Data Source
Authors
Klingmann,C., Knauth,M., Ries,S., Kern,R., Tasman,A. J.
Original/Translated Title
URL
Date of Electronic
PMCID
Editors
Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins 2002 Division of Infectious Diseases, Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA.
Source Type
Print(0)
Ref Type
Journal Article
Periodical, Full
Antimicrobial Agents and Chemotherapy
Periodical, Abbrev.
Antimicrob.Agents Chemother.
Pub Date Free Form
Jun
Volume
46
Issue
6
Start Page
1773
Other Pages
1780
Notes
LR: 20140612; GR: AI-36219/AI/NIAID NIH HHS/United States; GR: AI07024/AI/NIAID NIH HHS/United States; GR: AI35097-03/AI/NIAID NIH HHS/United States; GR: P30 CA43703-12/CA/NCI NIH HHS/United States; JID: 0315061; 0 (Anti-Bacterial Agents); 0 (Antifungal A
Place of Publication
United States
ISSN/ISBN
0066-4804; 0066-4804
Accession Number
PMID: 12019089
Language
eng
SubFile
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; IM
DOI
Output Language
Unknown(0)
PMID
12019089
Abstract
Biofilms, likely the predominant mode of device-related microbial infection, exhibit resistance to antimicrobial agents. Evidence suggests that Candida biofilms have dramatically reduced susceptibility to antifungal drugs. We examined antifungal susceptibilities of Candida albicans and Candida parapsilosis biofilms grown on a bioprosthetic model. In addition to conventional agents, we determined if new antifungal agents (triazoles, amphotericin B lipid formulations, and echinocandins) have activities against Candida biofilms. We also explored effects of preincubation of C. albicans cells with subinhibitory concentrations (sub-MICs) of drugs to see if they could modify subsequent biofilm formation. Finally, we used confocal scanning laser microscopy (CSLM) to image planktonic- and biofilm-exposed blastospores to examine drug effects on cell structure. Candida biofilms were formed on silicone elastomer and quantified by tetrazolium and dry weight (DW) assays. Susceptibility testing of fluconazole, nystatin, chlorhexidine, terbenafine, amphotericin B (AMB), and the triazoles voriconazole (VRC) and ravuconazole revealed resistance in all Candida isolates examined when grown as biofilms, compared to planktonic forms. In contrast, lipid formulations of AMB (liposomal AMB and AMB lipid complex [ABLC]) and echinocandins (caspofungin [Casp] and micafungin) showed activity against Candida biofilms. Preincubation of C. albicans cells with sub-MIC levels of antifungals decreased the ability of cells to subsequently form biofilm (measured by DW; P < 0.0005). CSLM analysis of planktonic and biofilm-associated blastospores showed treatment with VRC, Casp, and ABLC resulted in morphological alterations, which differed with each agent. In conclusion, our data show that Candida biofilms show unique susceptibilities to echinocandins and AMB lipid formulations.
Descriptors
Amphotericin B/administration & dosage/pharmacology, Anti-Bacterial Agents/pharmacology, Antifungal Agents/administration & dosage/pharmacology, Biofilms/drug effects, Candida/drug effects/ultrastructure, Culture Media, Drug Resistance, Microbial, Echinocandins, Fungal Proteins, Liposomes, Microbial Sensitivity Tests, Microscopy, Confocal, Peptides, Peptides, Cyclic, Polyenes/pharmacology, Prosthesis-Related Infections/microbiology, Triazoles/pharmacology
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Kuhn,D. M., George,T., Chandra,J., Mukherjee,P. K., Ghannoum,M. A.
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PMC127206
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