WTS database

Title	Pub Year	Author	SearchLink Sort descending
Online E-cigarette Marketing Claims: A Systematic Content and Legal Analysis	2016	Elizabeth G. Klein, Associate Professor, The Ohio State University College of Public Health, Columbus, OH. Micah Berman, Assistant Professor, The Ohio State University College of Public Health and Moritz College of Law, Columbus, OH. Natalie Hemmerich, Po	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Tobacco regulatory science Periodical, Abbrev. Tob Regul.Sci. Pub Date Free Form Jul Volume 2 Issue 3 Start Page 252 Other Pages 262 Notes LR: 20160725; GR: P50 CA180908/CA/NCI NIH HHS/United States; JID: 101655763; NIHMS799718; OTO: NOTNLM; 2016/07/01 [epublish]; ppublish Place of Publication ISSN/ISBN 2333-9748; 2333-9748 Accession Number PMID: 27446984 Language ENG SubFile JOURNAL ARTICLE DOI 10.18001/TRS.2.3.5 [doi] Output Language Unknown(0) PMID 27446984 Abstract OBJECTIVES: Electronic nicotine delivery systems (ENDS), or e-cigarettes, are heavily marketed online. The purpose of our study was to perform a systematic identification and evaluation of claims made within ENDS retailer and manufacturer websites, and the legal status of such claims. METHODS: We employed a systematic search protocol with popular search engines using 6 terms: (1) e-cigarettes; (2) e-cigs; (3) e-juice; (4) e-liquid; (5) e-hookah; and (6) vape pen. We analyzed English-language websites where ENDS are sold for implicit and explicit health-related claims. A legal analysis determined whether such claims are permissible under the US Food and Drug Administration's regulations. RESULTS: The vast majority of ENDS manufacturer (N = 78) and retailer (N = 32) websites made at least one health-related claim (77% and 65%, respectively). Modified risk claims and secondhand smoke-related claims were most prevalent, with an average of 2 claims per site. CONCLUSIONS: Health-related claims are plentiful within ENDS manufacturer and retailer websites. Results demonstrate that these sites focus on potential benefits while minimizing or eliminating information about possible harmful effects of ENDS. These claims are subject to the current regulatory authority by the FDA, and pose a risk of misinforming consumers. Descriptors Links Book Title Database Publisher Data Source Authors Klein,E.G., Berman,M., Hemmerich,N., Carlson,C., Htut,S., Slater,M. Original/Translated Title URL Date of Electronic 20160701 PMCID PMC4950517 Editors
Shisha Smoking Practices, Use Reasons, Attitudes, Health Effects and Intentions to Quit among Shisha Smokers in Malaysia	2016	Julius Centre University of Malaya (JCUM), Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. wonglp@ummc.edu.my.; Julius Centre University of Malaya (JCUM), Department of Social and Prev	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full International journal of environmental research and public health Periodical, Abbrev. Int.J.Environ.Res.Public.Health. Pub Date Free Form 19-Jul Volume 13 Issue 7 Start Page 10.3390/ijerph13070726 Other Pages Notes LR: 20160802; JID: 101238455; OID: NLM: PMC4962267; OTO: NOTNLM; 2016/05/04 [received]; 2016/05/20 [revised]; 2016/05/24 [accepted]; epublish Place of Publication Switzerland ISSN/ISBN 1660-4601; 1660-4601 Accession Number PMID: 27447655 Language eng SubFile Journal Article; IM DOI 10.3390/ijerph13070726 [doi] Output Language Unknown(0) PMID 27447655 Abstract Despite its popularity, shisha smoking practices, reasons for its use, attitudes, detrimental health effects and intention to quit among shisha users in Malaysia have never been investigated. A total of 503 shisha users responded to a cross-sectional study conducted between July 2015 and March 2016. The majority of users were young people aged 21-30; a small minority were underage. The reasons for shisha use were its growing popularity as a favourite pastime activity and the perception of shisha use as cool and trendy. Just over half (57.3%) agree that shisha use exposes the smoker to large amounts of smoke and the majority were unsure about the health risks of shisha smoking compared to tobacco smoking. The three most common detrimental health effects reported by the study respondents were dry throat, headache and nausea. Regular shisha users have significantly higher detrimental health effects compared to no-regular shisha users. Shisha users with a duration of smoking of 6-12 months (odds ratio (OR) 3.212; 95% confidence interval (CI) 1.651-6.248) and 6 months and below (OR 2.601; 95% CI 1.475-4.584) were significantly more likely to have a higher proportion who intend quitting smoking than shisha users of more than 12 months duration. Descriptors Links Book Title Database Publisher Data Source Authors Wong,L.P., Alias,H., Aghamohammadi,N., Aghazadeh,S., Hoe,V.C. Original/Translated Title URL Date of Electronic 20160719 PMCID PMC4962267 Editors
Drinking water contaminants from epoxy resin-coated pipes: A field study	2016	Masaryk University, Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Kamenice 753/5, Pavillion A29, 625 00, Brno, Czech Republic. Electronic address: johanna.rajasarkka@gmail.com.; Masaryk University, Faculty of Scienc	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Water research Periodical, Abbrev. Water Res. Pub Date Free Form 15-Jul Volume 103 Issue Start Page 133 Other Pages 140 Notes LR: 20160722; CI: Copyright (c) 2016; JID: 0105072; OTO: NOTNLM; 2016/05/20 [received]; 2016/06/22 [revised]; 2016/07/11 [accepted]; aheadofprint Place of Publication ISSN/ISBN 1879-2448; 0043-1354 Accession Number PMID: 27448038 Language ENG SubFile JOURNAL ARTICLE DOI S0043-1354(16)30531-0 [pii] Output Language Unknown(0) PMID 27448038 Abstract Rehabilitation of aged drinking water pipes is an extensive renovation and increasingly topical in many European cities. Spray-on-lining of drinking water pipes is an alternative cost-effective rehabilitation technology in which the insides of pipes are relined with organic polymer. A commonly used polymer is epoxy resin consisting of monomer bisphenol A (BPA). Leaching of BPA from epoxy lining to drinking water has been a concern among public and authorities. Currently epoxy lining is not recommended in some countries. BPA leaching has been demonstrated in laboratory studies but the behavior and ageing process of epoxy lining in situ is not well known. In this study 6 locations with different age epoxy linings of drinking water pipes done using two distinct technologies were studied. While bisphenol F, 4-n-nonylphenol, and 4-t-octylphenol were rarely found and in trace concentrations, BPA was detected in majority of samples. Pipes lined with the older technology (LSE) leached more BPA than those with more recent technology (DonPro): maxima in cold water were 0.25 mug/L and 10 ng/L, respectively. Incubation of water in pipes 8-10 h prior to sampling increased BPA concentration in cold water 1.1-43-fold. Hot water temperature caused even more BPA leaching - at maximum 23.5 mug/L. The influence of ageing of epoxy lining on BPA leaching on could be shown in case of LSE technology: locations with 8-9 years old lining leached 4-20-fold more BPA compared to a location with 2-year-old lining. Analysis of metals showed that epoxy lining can reduce especially iron concentration in water. No significant burden to water could be shown by the analyzed 72 volatile organic compounds, including epichlorhydrin, precursor used in epoxy resin. Estrogenicity was detected in water samples with the highest BPA loads. Comparable responses of two yeast bioreporters (estrogen receptor alpha and BPA-targeted) indicated that bisphenol-like compounds were the main cause of estrogenicity. Compared to the estimated average daily BPA exposure, additional BPA load via cold drinking water in the studied locations was low, maximum 8.7%. However, hot water should also be considered as exposure source due to higher BPA concentrations. Epoxy lined locations should be monitored in future in order to evaluate ageing process and control increasing leaching of potentially harmful chemicals. Descriptors Links Book Title Database Publisher . Published by Elsevier Ltd Data Source Authors Rajasarkka,J., Pernica,M., Kuta,J., Lasnak,J., Simek,Z., Blaha,L. Original/Translated Title URL Date of Electronic 20160715 PMCID Editors
Use of multiple tobacco products in a national sample of persons enrolled in addiction treatment	2016	Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, 3333 California St., Ste. 265, San Francisco, CA 94118, United States. Electronic address: joseph.guydish@ucsf.edu.; Philip R. Lee Institute for Health Policy Studi	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Drug and alcohol dependence Periodical, Abbrev. Drug Alcohol Depend. Pub Date Free Form 1-Sep Volume 166 Issue Start Page 93 Other Pages 99 Notes LR: 20160815; CI: Copyright (c) 2016; GR: P50 DA009253/DA/NIDA NIH HHS/United States; GR: R01 DA036066/DA/NIDA NIH HHS/United States; JID: 7513587; NIHMS802871; OID: NLM: NIHMS802871 [Available on 09/01/17]; OID: NLM: PMC4983463 [Available on 09/01/17]; O Place of Publication Ireland ISSN/ISBN 1879-0046; 0376-8716 Accession Number PMID: 27449271 Language eng SubFile Journal Article; IM DOI 10.1016/j.drugalcdep.2016.06.035 [doi] Output Language Unknown(0) PMID 27449271 Abstract OBJECTIVE: To explore use of tobacco products in relationship to marketing exposure among persons in addiction treatment. METHOD: A random sample of treatment programs was drawn from the National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN). Participants in each program completed surveys concerning use of tobacco products (N=1113). Exposure to tobacco marketing and counter-marketing, advertising receptivity, and perceived health risks of smoking were tested for their association with use of multiple tobacco products. RESULTS: Prevalence of combustible cigarette use was 77.9%. Weekly or greater use of other products was: e-cigarettes (17.7%), little filtered cigars (8.6%), smokeless tobacco (5.2%), and standard cigars (4.6%) with 24.4% using multiple tobacco products. Compared to single product users, multiple product users smoked more cigarettes per day (OR=1.03, 95% CI 1.01-1.05, p Descriptors Links Book Title Database Publisher Elsevier Ireland Ltd Data Source Authors Guydish,J., Tajima,B., Pramod,S., Le,T., Gubner,N.R., Campbell,B., Roman,P. Original/Translated Title URL Date of Electronic 20160714 PMCID PMC4983463 Editors
Depressive symptoms and bone mineral density in menopause and postmenopausal women: A still increasing and neglected problem	2016	Department of Biostatistics and Medical Informatics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Journal of family medicine and primary care Periodical, Abbrev. J.Family Med.Prim.Care. Pub Date Free Form Jan-Mar Volume 5 Issue 1 Start Page 143 Other Pages 149 Notes LR: 20160729; JID: 101610082; OID: NLM: PMC4943122; OTO: NOTNLM; ppublish Place of Publication India ISSN/ISBN 2249-4863; 2249-4863 Accession Number PMID: 27453860 Language eng SubFile Journal Article DOI 10.4103/2249-4863.184640 [doi] Output Language Unknown(0) PMID 27453860 Abstract BACKGROUND: The association between depression and loss of bone mineral density (BMD) has been reported as controversial. OBJECTIVE: The objective of the current study was to investigate whether an association exists between depression and low BMD during the menopausal and postmenopausal period. MATERIALS AND METHODS: A cross-sectional descriptive study was used to generate menopause symptoms experienced by Arabian women at the Primary Health Care Centers in Qatar. A multi-stage sampling design was used, and a representative sample of 1650 women aged 45-65 years were included during July 2012 and November 2013. This prospective study explored the association between bone density and major depressive disorder in women. Bone mineral densitometry measurements (BMD) (g/m(2)) were assessed at the BMD unit using a lunar prodigy DXA system (Lunar Corp., Madison, WI). Data on body mass index (BMI), clinical biochemistry variables including serum 25-hydroxyvitamin D were collected. The Beck Depression Inventory was administered for depression purposes. RESULTS: Out of 1650 women 1182 women agreed to participate in the study (71.6%). The mean age and standard deviation (SD) of the menopausal age were 48.71 +/- 2.96 with depressed and 50.20 +/- 3.22 without depressed (P Descriptors Links Book Title Database Publisher Data Source Authors Bener,A., Saleh,N.M., Bhugra,D. Original/Translated Title URL Date of Electronic PMCID PMC4943122 Editors
Impact of Partial and Comprehensive Smoke-Free Regulations on Indoor Air Quality in Bars	2016	Department of Environmental Health, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea. xellos88@naver.com.; Department of Environmental Health Research, Seoul Medical Center, 156 Sinnae-ro, Jungnang-	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full International journal of environmental research and public health Periodical, Abbrev. Int.J.Environ.Res.Public.Health. Pub Date Free Form 26-Jul Volume 13 Issue 8 Start Page 10.3390/ijerph13080754 Other Pages Notes JID: 101238455; OTO: NOTNLM; 2016/05/30 [received]; 2016/07/16 [revised]; 2016/07/19 [accepted]; epublish Place of Publication Switzerland ISSN/ISBN 1660-4601; 1660-4601 Accession Number PMID: 27472349 Language eng SubFile Journal Article; IM DOI 10.3390/ijerph13080754 [doi] Output Language Unknown(0) PMID 27472349 Abstract In Korea, smoke-free regulations have been gradually implemented in bars based on venue size. Smoking bans were implemented in 2013 for bars >/=150 m(2), in 2014 for bars >/=100 m(2), and in 2015 for bars of all sizes. The purpose of this study was to determine indoor fine particle (PM2.5) concentrations in bars before and after implementation of the smoke-free policies based on venue size. Indoor PM2.5 concentrations were measured with real-time aerosol monitors at four time points: (1) pre-regulation (n = 75); (2) after implementing the ban in bars >/=150 m(2) (n = 75); (3) after implementing the ban in bars >/=100 m(2) (n = 107); and (4) when all bars were smoke-free (n = 79). Our results showed that the geometric mean of the indoor PM2.5 concentrations of all bars decreased from 98.4 mug/m(3) pre-regulation to 79.5, 42.9, and 26.6 mug/m(3) after the ban on smoking in bars >/=150 m(2), >/=100 m(2), and all bars, respectively. Indoor PM2.5 concentrations in bars of each size decreased only after the corresponding regulations were implemented. Although smoking was not observed in Seoul bars after smoking was banned in all bars, smoking was observed in 4 of 21 bars in Changwon. Our study concludes that the greatest decrease in PM2.5 concentrations in bars was observed after the regulation covering all bars was implemented. However, despite the comprehensive ban, smoking was observed in bars in Changwon. Strict compliance with the regulations is needed to improve indoor air quality further. Descriptors Links Book Title Database Publisher Data Source Authors Kim,J., Ban,H., Hwang,Y., Ha,K., Lee,K. Original/Translated Title URL Date of Electronic 20160726 PMCID Editors
Exposure to waterpipe smoke induces renal functional and oxidative biomarkers variations in mice	2016	a Department of Clinical Pharmacy , Faculty of Pharmacy .; b Department of Forensic Medicine and Toxicology , Faculty of Medicine .; a Department of Clinical Pharmacy , Faculty of Pharmacy .; c Department of Medical Laboratory Sciences , Faculty of Applie	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Inhalation toxicology Periodical, Abbrev. Inhal.Toxicol. Pub Date Free Form 1-Aug Volume Issue Start Page 1 Other Pages 6 Notes LR: 20160801; JID: 8910739; OTO: NOTNLM; aheadofprint; SO: Inhal Toxicol. 2016 Aug 1:1-6. Place of Publication ISSN/ISBN 1091-7691; 0895-8378 Accession Number PMID: 27477853 Language ENG SubFile JOURNAL ARTICLE DOI 10.1080/08958378.2016.1210703 [doi] Output Language Unknown(0) PMID 27477853 Abstract CONTEXT: Waterpipe smoking (WPS) has been known for over 400 years. It has been spread widely especially between youth because of the addition of pleasant flavor and because it was misconsidered to be less harmful than cigarette. OBJECTIVE: In this study, we investigated the effect of waterpipe smoking on renal oxidative and functional parameters and compared that at acute and chronic exposure time in mice. MATERIALS AND METHODS: Mice were divided into three groups, namely acute, chronic and fresh air control. Acute group was exposed to waterpipe smoke for one hour daily for six days using whole-body exposure system, while chronic group was exposed to waterpipe smoke for one hour daily for 30 days using whole-body exposure system. RESULT: Exposure to waterpipe smoke has shown significant changes on the mice kidney functional parameters such as creatinine and blood urea nitrogen. Both exposures (acute and chronic) has shown a significant reduction in superoxide dismutase (SOD) activity (p Descriptors Links Book Title Database Publisher Data Source Authors Rababa'h,A.M., Sultan,B.B., Alzoubi,K.H., Khabour,O.F., Ababneh,M.A. Original/Translated Title URL Date of Electronic 20160801 PMCID Editors
Facility-Based Delivery during the Ebola Virus Disease Epidemic in Rural Liberia: Analysis from a Cross-Sectional, Population-Based Household Survey	2016	Medical Team, Last Mile Health, Zwedru, Liberia.; Monitoring and Evaluation Team, Last Mile Health, Zwedru, Liberia.; Monitoring and Evaluation Team, Last Mile Health, Zwedru, Liberia.; Division of Global Health Equity, Brigham and Women's Hospital, Bosto	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full PLoS medicine Periodical, Abbrev. PLoS Med. Pub Date Free Form 2-Aug Volume 13 Issue 8 Start Page e1002096 Other Pages Notes LR: 20160819; JID: 101231360; OID: NLM: PMC4970816; 2016/08 [ecollection]; 2015/06/11 [received]; 2016/06/17 [accepted]; 2016/08/02 [epublish]; epublish Place of Publication United States ISSN/ISBN 1549-1676; 1549-1277 Accession Number PMID: 27482706 Language eng SubFile Journal Article; IM DOI 10.1371/journal.pmed.1002096 [doi] Output Language Unknown(0) PMID 27482706 Abstract BACKGROUND: The Ebola virus disease (EVD) epidemic has threatened access to basic health services through facility closures, resource diversion, and decreased demand due to community fear and distrust. While modeling studies have attempted to estimate the impact of these disruptions, no studies have yet utilized population-based survey data. METHODS AND FINDINGS: We conducted a two-stage, cluster-sample household survey in Rivercess County, Liberia, in March-April 2015, which included a maternal and reproductive health module. We constructed a retrospective cohort of births beginning 4 y before the first day of survey administration (beginning March 24, 2011). We then fit logistic regression models to estimate associations between our primary outcome, facility-based delivery (FBD), and time period, defined as the pre-EVD period (March 24, 2011-June 14, 2014) or EVD period (June 15, 2014-April 13, 2015). We fit both univariable and multivariable models, adjusted for known predictors of facility delivery, accounting for clustering using linearized standard errors. To strengthen causal inference, we also conducted stratified analyses to assess changes in FBD by whether respondents believed that health facility attendance was an EVD risk factor. A total of 1,298 women from 941 households completed the survey. Median age at the time of survey was 29 y, and over 80% had a primary education or less. There were 686 births reported in the pre-EVD period and 212 in the EVD period. The unadjusted odds ratio of facility-based delivery in the EVD period was 0.66 (95% confidence interval [CI] 0.48-0.90, p-value = 0.010). Adjustment for potential confounders did not change the observed association, either in the principal model (adjusted odds ratio [AOR] = 0.70, 95%CI 0.50-0.98, p = 0.037) or a fully adjusted model (AOR = 0.69, 95%CI 0.50-0.97, p = 0.033). The association was robust in sensitivity analyses. The reduction in FBD during the EVD period was observed among those reporting a belief that health facilities are or may be a source of Ebola transmission (AOR = 0.59, 95%CI 0.36-0.97, p = 0.038), but not those without such a belief (AOR = 0.90, 95%CI 0.59-1.37, p = 0.612). Limitations include the possibility of FBD secular trends coincident with the EVD period, recall errors, and social desirability bias. CONCLUSIONS: We detected a 30% decreased odds of FBD after the start of EVD in a rural Liberian county with relatively few cases. Because health facilities never closed in Rivercess County, this estimate may under-approximate the effect seen in the most heavily affected areas. These are the first population-based survey data to show collateral disruptions to facility-based delivery caused by the West African EVD epidemic, and they reinforce the need to consider the full spectrum of implications caused by public health emergencies. Descriptors Links Book Title Database Publisher Data Source Authors Ly,J., Sathananthan,V., Griffiths,T., Kanjee,Z., Kenny,A., Gordon,N., Basu,G., Battistoli,D., Dorr,L., Lorenzen,B., Thomson,D.R., Waters,A., Moore,U.G., Roberts,R., Smith,W.L., Siedner,M.J., Kraemer,J.D. Original/Translated Title URL Date of Electronic 20160802 PMCID PMC4970816 Editors
Bacterial repopulation of drinking water pipe walls after chlorination	2016	a EPHE , PSL Research University, Laboratoire de Chimie Physique et Microbiologie pour l'Environnement, LCPME , UMR 7564 , Nancy , France.; b CNRS and Universite de Lorraine, Laboratoire de Chimie Physique et Microbiologie pour l'Environnement, LCPME , UM	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Biofouling Periodical, Abbrev. Biofouling Pub Date Free Form Sep Volume 32 Issue 8 Start Page 925 Other Pages 934 Notes JID: 9200331; OTO: NOTNLM; ppublish Place of Publication England ISSN/ISBN 1029-2454; 0892-7014 Accession Number PMID: 27483985 Language eng SubFile Journal Article; IM DOI 10.1080/08927014.2016.1212989 [doi] Output Language Unknown(0) PMID 27483985 Abstract The short-term kinetics of bacterial repopulation were evaluated after chlorination of high-density polyethylene (HDPE) colonized with drinking water biofilms and compared with bare HDPE surfaces. The effect of chlorination was partial as a residual biofilm persisted and was time-limited as repopulation occurred immediately after water resupply. The total number of bacteria reached the same levels on both the bare and chlorinated biofilm-fouled HDPE after a seven-day exposure to drinking water. Due to the presence of a residual biofilm, the hydrophobicity of chlorinated biofilm-fouled surface exhibited much lower adhesion forces (2.1 nN) compared to bare surfaces (8.9 nN). This could explain the rapid repopulation after chlorination, with a twofold faster bacterial accumulation rate on the bare HDPE surface. gamma-Proteobacteria dominated the early stages of repopulation of both surfaces and a shift in the dominance occurred over the colonization time. Such observations define a timescale for cleaning frequency in industrial environments and guidelines for a rinsing procedure using drinking water. Descriptors Links Book Title Database Publisher Data Source Authors Mathieu,L., Francius,G., El Zein,R., Angel,E., Block,J.C. Original/Translated Title URL Date of Electronic PMCID Editors
Identification of Novel Structurally Diverse Anaplastic Lymphoma Kinase Inhibitors Based on Pharmacophore Modeling, Virtual Screening and Molecular Docking	2016	College of Chemical Engineering, Sichuan University, Sichuan, Chengdu 610065, China.	Read more...
Source Type Print(0) Ref Type Journal Article Periodical, Full Combinatorial chemistry & high throughput screening Periodical, Abbrev. Comb.Chem.High Throughput Screen. Pub Date Free Form 1-Aug Volume Issue Start Page Other Pages Notes LR: 20160804; JID: 9810948; 2016/03/21 [received]; 2016/06/24 [revised]; 2016/07/22 [accepted]; aheadofprint Place of Publication ISSN/ISBN 1875-5402; 1386-2073 Accession Number PMID: 27487788 Language ENG SubFile JOURNAL ARTICLE DOI CCHTS-EPUB-77482 [pii] Output Language Unknown(0) PMID 27487788 Abstract Anaplastic lymphoma kinase, an insulin receptor protein-tyrosine kinase, is a very attractive receptor protein target for anticancer therapy. Pharmacophore hypotheses modeling, virtual screening and molecular docking were used to detect potential inhibitors of anaplastic lymphoma kinase in this paper. After the generation of ten pharmacophore hypotheses, Hypo1 with the highest correlation value (0.981), lowest RMS (0.565), highest cost difference (83.850) along with four typical chemical features was regarded as the best hypothesis. Hypo1 contains a hydrogen bond acceptor, a hydrogen bong donor, a hydrophobic and a ring aromatic feature. And then, hypo1 was validated and used to screen three databases after screened by Lipinski's rule of five. 3015 hits screened by Hypo1 were submitted to molecular docking based on the crystal structure of anaplastic lymphoma kinase. Ultimately, 7 molecules with four different scaffolds were selected as potential leads for designing the anaplastic lymphoma kinase inhibitors. Descriptors Links Book Title Database Publisher Data Source Authors You,R., Zhou,L., Zhong,L., Li,X., Zhou,S., Tian,Y. Original/Translated Title URL Date of Electronic 20160801 PMCID Editors

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