We welcome the Director-General’s Report and the historic adoption of the Pandemic Agreement.

However, the current global architecture for health emergencies underestimate, that similar to COVID-19, every future disease outbreak or pandemic will face escalated risks of Sepsis, as the final common pathway to death and disability.

Armed conflicts, climate crisis or displacement will also expose civilians, healthcare professionals, humanitarian workers or military and peacekeeping forces to increased risks of infection and Sepsis.

Therefore, the global architecture for health emergencies, must prioritize stronger risk communication, surveillance and capacity building for Sepsis prevention and management. This shall be supported by increased R&D for new vaccines, antimicrobial therapies, and pathogen-agnostic systems immunology approaches.