WHO recommendation on the use of tranexamic acid for the treatment of postpartum haemorrhage (PPH)

WHO recommendation on the use of tranexamic acid for the treatment of postpartum haemorrhage (PPH)

Recommendation

 

  • The use of tranexamic acid is recommended for the treatment of PPH if oxytocin and other uterotonics fail to stop the bleeding or if it is thought that the bleeding may be partly due to trauma. (Weak recommendation, moderate-quality evidence)

 

Date this recommendation was published: September 2012

 

Remarks

Evidence for the recommendation of tranexamic acid was extrapolated from the literature on surgery and trauma, which shows tranexamic acid to be a safe option for the treatment of trauma-related bleeding

 

Related links

WHO recommendations for the prevention and treatment of postpartum haemorrhage

Evidence Base and GRADE tables for this recommendation

 

Links to the supporting systematic reviews

Novikova N, Hofmeyr GJ. Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database Syst Rev. 2010(7):CD007872.

Shakur H, Elbourne D, Gulmezoglu M, Alfirevic Z, Ronsmans C, Allen E, et al. The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. Trials.11:40. 67.

Ferrer PR, Sydenham EI, Blackhall K, Shakur H. Anti-fibrinolytic agents in obstetric haemorrhage: a systematic review. BMC Pregnancy Childbirth

 

This recommendation should be cited as: WHO Reproductive Health Library. WHO recommendation on the use of tranexamic acid for the treatment of postpartum haemorrhage (last revised 2012). The WHO Reproductive Health Library; Geneva: World Health Organization.