Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection

Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection

March 2015

Authors:
WHO

Publication details

Number of pages: 166
Publication date: March 2015
Languages: English
ISBN: 978 92 4 154905 9

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Overview

These are the first World Health Organization (WHO) guidelines for theprevention, care and treatment of persons living with chronic hepatitis B (CHB) infection, andcomplement similar recently published guidance by WHO on the prevention,care and treatment of infection due to the hepatitis C virus (HCV).

The recommendations in these guidelines promote the use of simple, non-invasive diagnostic tests to assess the stage of liver disease and eligibility for treatment; prioritize treatment for those with mostadvanced liver disease and at greatest risk of mortality; and recommend thepreferred use of nucleos(t)ide analogues with a high barrier to drug resistance(tenofovir and entecavir, and entecavir in children aged 2–11 years) for first- andsecond-line treatment. Recommendations for the treatment of HBV/HIV-coinfected persons are basedon the WHO 2013 Consolidated guidelines on the use of antiretroviral drugsfor treating and preventing HIV infection, which will be updated in 2015.

These recommendations provide opportunities to save lives, improve clinicaloutcomes of persons living with CHB, reduce HBV incidence and transmission,and stigma due to disease, but they also pose practical challenges to policymakersand implementers in low- and middle-income countries.

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