Journal Article

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Antimicrobial Agents and Chemotherapy

Antimicrob.Agents Chemother.

Jul

55

7

3591

3593

LR: 20150204; GR: R21AI080930/AI/NIAID NIH HHS/United States; JID: 0315061; 0 (Antifungal Agents); 0 (Echinocandins); 7XU7A7DROE (Amphotericin B); 8VZV102JFY (Fluconazole); F0XDI6ZL63 (caspofungin); OID: NLM: PMC3122381; 2011/04/25 [aheadofprint]; ppublis

United States

1098-6596; 0066-4804

PMID: 21518839

eng

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM

10.1128/AAC.01701-10 [doi]

Unknown(0)

21518839

We have examined the effect of continuous perfusion with antifungals on Candida albicans biofilms under conditions of flow, closely mimicking physiological conditions encountered within patients. Biofilms displayed high levels of resistance to fluconazole, and this antifungal exerted minor effects on dispersion levels. Amphotericin B proved effective in reducing viability of cells within the biofilms and dispersion, but only at high concentrations. Under flow conditions, caspofungin exhibited potent activity against biofilms and drastically reduced biofilm dispersion.

Uppuluri,P., Srinivasan,A., Ramasubramanian,A., Lopez-Ribot,J.L.

Department of Biology, South Texas Center for Emerging Infectious Diseases,The University of Texas at San Antonio, San Antonio, Texas 78249, USA.

20110425

PMC3122381

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=21518839

2011