Comparison of nicotine and carcinogen exposure with water pipe and cigarette smoking

Journal Article

Print(0)

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Cancer Epidemiol.Biomarkers Prev.

May

765

772

LR: 20160408; GR: DA012393/DA/NIDA NIH HHS/United States; GR: P30 DA012393/DA/NIDA NIH HHS/United States; GR: UL1 RR024131/RR/NCRR NIH HHS/United States; JID: 9200608; 0 (Biomarkers); 0 (Carcinogens); 6M3C89ZY6R (Nicotine); NIHMS451482; OID: NLM: NIHMS451

United States

1538-7755; 1055-9965

PMID: 23462922

eng

Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; IM

10.1158/1055-9965.EPI-12-1422 [doi]

Unknown(0)

23462922

BACKGROUND: Smoking tobacco preparations in a water pipe (hookah) is widespread in many places of the world and is perceived by many as relatively safe. We investigated biomarkers of toxicant exposure with water pipe compared with cigarette smoking. METHODS: We conducted a crossover study to assess daily nicotine and carcinogen exposure with water pipe and cigarette smoking in 13 people who were experienced in using both products. RESULTS: When smoking an average of 3 water pipe sessions compared with smoking 11 cigarettes per day (cpd), water pipe use was associated with a significantly lower intake of nicotine, greater exposure to carbon monoxide (CO), and a different pattern of carcinogen exposure compared with cigarette smoking, with greater exposure to benzene, and high molecular weight polycyclic aromatic hydrocarbon (PAH), but less exposure to tobacco-specific nitrosamines, 1,3-butadiene, acrolein, acrylonitrile, propylene oxide, ethylene oxide, and low molecular weight PAHs. CONCLUSIONS: A different pattern of carcinogen exposure might result in a different cancer risk profile between cigarette and water pipe smoking. Of particular concern is the risk of leukemia related to high levels of benzene exposure with water pipe use. IMPACT: Smoking tobacco in water pipes has gained popularity in the United States and around the world. Many believe that water pipe smoking is not addictive and less harmful than cigarette smoking. We provide data on toxicant exposure that will help guide regulation and public education regarding water pipe health risk.

Jacob,P.,3rd, Abu Raddaha,A.H., Dempsey,D., Havel,C., Peng,M., Yu,L., Benowitz,N.L.

Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, Building 100, Room 235, San Francisco, CA 94110, USA. peyton.jacob@ucsf.edu

20130305

PMC3650103

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=23462922

2013