Journal Article

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Journal of periodontology

J.Periodontol.

Jan

72

1

43

49

LR: 20071115; JID: 8000345; ppublish

United States

0022-3492; 0022-3492

PMID: 11210072

eng

Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; D; IM

10.1902/jop.2001.72.1.43 [doi]

Unknown(0)

11210072

BACKGROUND: The purpose of the present parallel design, controlled clinical trial was to evaluate the treatment outcome following flap debridement surgery (FDS) in cigarette smokers compared to non-smokers. METHODS: After initial therapy, 57 systemically healthy subjects with moderate to advanced periodontitis who presented with one area (at least 3 teeth) where surgery was required were selected. Twenty-eight patients (mean age: 39.6 years, 20 males) were smokers (> or = 10 cigarettes/day); 29 patients (mean age: 43.9 years, 7 males) were non-smokers. Full-mouth plaque (FMP) and bleeding on probing (BOP) scores, probing depth (PD), clinical attachment level (CAL), and recession depth (RD) were assessed immediately before and 6 months following surgery. Only sites with presurgery PD > or = 4 mm were used for statistical analysis. RESULTS: Presurgery FMP and BOP were similar in smokers and non-smokers and significantly decreased postsurgery in both groups. Overall, PD reduction and CAL gain were greater, although not significantly, in non-smokers (2.4 +/- 0.9 mm and 1.6 +/- 0.7 mm, respectively) than in smokers (1.9 +/- 0.7 mm and 1.2 +/- 0.7 mm, respectively). For moderate sites (PD 4 to 6 mm), no significant differences in PD and CAL changes were found between groups. For deep sites (PD > or = 7 mm), PD reduction was 3.0 +/- 1.0 mm in smokers and 4.0 +/- 0.8 mm in non-smokers, and CAL gain amounted to 1.8 +/- 1.1 mm in smokers and 2.8 +/- 1.0 mm in non-smokers (P = 0.0477). In smokers, 16% of deep sites healed to postsurgery PD values or = 2 mm, as compared to 82% in non-smokers (P = 0.0000). CONCLUSIONS: Results of the study indicated that: 1) FDS determined a statistically significant PD reduction and CAL gain in patients with moderate to advanced periodontitis; 2) smokers exhibited a trend towards less favorable healing response following FDS compared to non-smokers, both in terms of PD reduction and CAL gain; and 3) this trend reached clinical and statistical significance at sites with initial deep PD.

Adult, Aged, Chi-Square Distribution, Confidence Intervals, Debridement, Dental Plaque Index, Female, Follow-Up Studies, Gingival Hemorrhage/surgery, Gingival Recession/surgery, Humans, Male, Middle Aged, Periodontal Attachment Loss/surgery, Periodontal Index, Periodontal Pocket/surgery, Periodontitis/surgery, Single-Blind Method, Smoking/adverse effects, Statistics as Topic, Surgical Flaps, Treatment Outcome, Wound Healing

Scabbia,A., Cho,K. S., Sigurdsson,T. J., Kim,C. K., Trombelli,L.

Research Center for the Study of Periodontal Diseases, University of Ferrara, Italy.

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=11210072

2001