Journal Article

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Natural product research

Nat.Prod.Res.

May

25

9

918

926

LR: 20131121; JID: 101167924; 0 (Antioxidants); 0 (Flavonoids); 0 (Glycosides); 9IKM0I5T1E (Quercetin); ppublish

England

1478-6427; 1478-6419

PMID: 21547843

eng

Journal Article; IM

10.1080/14786419.2010.490214 [doi]

Unknown(0)

21547843

Activity-guided fractionation of the ethanolic extract of the leaves of the Polyalthia longifolia var. pendula led to the identification of quercetin (1), quercetin-3-O-beta-glucopyranoside (2), kaempferol-3-O-alpha-rhamnopyranosyl-(1 --> 6)-beta-galactopyranoside (3), kaempferol-3-O-alpha-rhamnopyranosyl-(1 --> 6)-beta-glucopyranoside (4), rutin (5) and allantoin (6) as the active constituents from the butanol fraction. Compounds 2-4 are reported for the first time from this natural source. Structures of the compounds were confirmed on the basis of their 1D and 2D NMR coupled with other spectroscopic methods. All the isolated compounds and the fractions were evaluated for their antioxidant potential using the TEAC assays and it was found that the activity of the active fraction was due to quercetin (1) and its glycosides (2 and 5), with TEAC values of 4.10, 1.91 and 2.38 mM, respectively, while the kaempferol glycosides were found to be inactive. This is the first study on the antioxidant activity of this plant species.

Sashidhara,K.V., Singh,S.P., Srivastava,A., Puri,A.

Division of Medicinal and Process Chemistry, Central Drug Research Institute (CSIR), Uttar Pradesh, India. sashidhar123@gmail.com

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=21547843

2011