Journal Article

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Gastroenterology clinics of North America

Gastroenterol.Clin.North Am.

Mar

43

1

1

14

CI: Published by Elsevier Inc.; JID: 8706257; Adenocarcinoma Of Esophagus; OTO: NOTNLM; 2013/12/27 [aheadofprint]; ppublish

United States

1558-1942; 0889-8553

PMID: 24503355

eng

Journal Article; Review; IM

10.1016/j.gtc.2013.11.006 [doi]

Unknown(0)

24503355

The prevalence of gastroesophageal reflux disease (GERD) symptoms increased approximately 50% until the mid-1990s, when it plateaued. The incidence of complications related to GERD including hospitalization, esophageal strictures, esophageal adenocarcinoma, and mortality also increased during that time period, but the increase in esophageal adenocarcinoma has since slowed, and the incidence of strictures has decreased since the mid-1990s. GERD is responsible for the greatest direct costs in the United States of any gastrointestinal disease, and most of those expenditures are for pharmacotherapy. Risk factors for GERD include obesity, poor diet, lack of physical activity, consumption of tobacco and alcohol, and respiratory diseases.

Rubenstein,J.H., Chen,J.W.

Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI, USA; Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: jhr@umich.edu.; Division of Gastroenterology, University of Michigan

20131227

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=24503355

2014