Cigarette smoking and the risk of Barrett's esophagus

Journal Article

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Cancer causes & control : CCC

Cancer Causes Control

Apr

303

311

LR: 20151119; GR: F32 DK081271/DK/NIDDK NIH HHS/United States; GR: K08 DK 002697/DK/NIDDK NIH HHS/United States; GR: K08 DK002697/DK/NIDDK NIH HHS/United States; GR: K08 DK002697-05/DK/NIDDK NIH HHS/United States; GR: R01 DK 63616/DK/NIDDK NIH HHS/United

Netherlands

1573-7225; 0957-5243

PMID: 18853262

eng

Journal Article; Research Support, N.I.H., Extramural; IM

10.1007/s10552-008-9244-4 [doi]

Unknown(0)

18853262

INTRODUCTION: We examined the association between smoking and the risk of Barrett's esophagus (BE), a metaplastic precursor to esophageal adenocarcinoma. METHODS: We conducted a case-control study within the Kaiser Permanente Northern California population. Patients with a new diagnosis of BE (n = 320) were matched to persons with gastroesophageal reflux disease (GERD) (n = 316) and to population controls (n = 317). Information was collected using validated questionnaires from direct in-person interviews and electronic databases. Analyses used multivariate unconditional logistic regression that controlled for age, gender, race, and education. RESULTS: Ever smoking status, smoking intensity (pack-years), and smoking cessation were not associated with the risk of BE. Stratified analyses suggested that ever smoking may be associated with an increased risk of BE among some groups (compared to population controls): persons with long-segment Barrett's esophagus (odds ratio [OR] = 1.72, 95% confidence interval [CI] 1.12-2.63); subjects without GERD symptoms (OR = 3.98, 95% CI 1.58-10.0); obese subjects (OR = 3.38, 95% CI 1.46-7.82); and persons with a large abdominal circumference (OR = 3.02, 95% CI (1.18-2.75)). CONCLUSION: Smoking was not a strong or consistent risk factor for BE in a large community-based study, although associations may be present in some population subgroups.

Adenocarcinoma/epidemiology, Adolescent, Adult, Aged, Alcohol Drinking/adverse effects, Barrett Esophagus/epidemiology, Body Mass Index, California/epidemiology, Case-Control Studies, Confidence Intervals, Confounding Factors (Epidemiology), Databases, Factual, Esophageal Neoplasms/epidemiology, Gastroesophageal Reflux/epidemiology, Geography, Humans, Incidence, Interviews as Topic, Logistic Models, Middle Aged, Obesity/complications, Odds Ratio, Precancerous Conditions/complications, Reproducibility of Results, Risk Factors, Smoking/adverse effects, Surveys and Questionnaires, Young Adult

Kubo,A., Levin,T. R., Block,G., Rumore,G., Quesenberry,C. P.,Jr, Buffler,P., Corley,D. A.

Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA. ai.kubo@kp.org

20081014

PMC2649684

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=18853262

2009