Autophagy and its current relevance to the diagnosis and clinical management of esophageal diseases

Journal Article

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Annals of the New York Academy of Sciences

Ann.N.Y.Acad.Sci.

15-Aug

1749-6632; 0077-8923

PMID: 27526024

ENG

JOURNAL ARTICLE

10.1111/nyas.13190 [doi]

Unknown(0)

27526024

Autophagy is an evolutionarily conserved cell survival program that degrades dysfunctional organelles and misfolded or long-lived proteins through the formation of lysosomes. Basal autophagy helps to maintain cellular homeostasis, while additional autophagy can be induced under cellular stress conditions. Autophagy has shown to be involved in a variety of diseases, such as inflammation, autoimmune diseases, degeneration, and cancer. We review the relevance of autophagy to the diagnosis and clinical management of esophageal diseases with the following questions in mind. What is autophagy and can/should we detect it in routine pathology specimens? What is the role of autophagy in gastroesophageal reflux disease/inflammatory esophageal disease? What role may autophagy play in the interaction between pro- and antiapoptotic pathways in esophageal malignancies and treatment?

New York Academy of Sciences

Langer,R., Streutker,C.J., Swanson,P.E.

Institute of Pathology, University of Bern, Bern, Switzerland.; Li Ka Shing Institute, St. Michael's Hospital and Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Canada.; Cumming School of Medicine, University of Calgary

20160815

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=27526024

2016