Journal Article

Print(0)

Journal of natural products

J.Nat.Prod.

Jun

72

6

1057

1060

LR: 20131121; JID: 7906882; 0 (Antiviral Agents); 0 (Drugs, Chinese Herbal); 0 (Glycosides); 0 (Umbelliferones); 9IKM0I5T1E (Quercetin); SM2XD6V944 (esculetin); ppublish

United States

1520-6025; 0163-3864

PMID: 19422205

eng

Journal Article; Research Support, Non-U.S. Gov't; IM

10.1021/np800760p [doi]

Unknown(0)

19422205

Five new 7-O-methylkaempferol and -quercetin glycosides, namely, nervilifordins A-E (1-5), were isolated from the whole plant of Nervilia fordii, together with seven known flavonoids (6, 7, and 9-13) and one known coumarin (8). Their structures were elucidated on the basis of extensive spectroscopic analyses, including HSQC, HMBC, ROESY, and chemical methods. Compounds 1-3 and 6-13 were evaluated for their anti-herpes simplex virus 1 (HSV-1) activity and cytotoxicity on African green monkey kidney cells (Vero cells) in vitro. Of the tested compounds, only esculetin (8) exhibited antiviral activity against HSV-1, while the aglycones (11-13) showed stronger cytotoxicity on Vero cells than their glycosides (1-3, 6, and 7).

Animals, Antiviral Agents/chemistry/isolation & purification/pharmacology, Cercopithecus aethiops, Drugs, Chinese Herbal/chemistry/isolation & purification/pharmacology, Glycosides/chemistry/isolation & purification/pharmacology, Herpesvirus 1, Human/drug effects, Orchidaceae/chemistry, Plants, Medicinal/chemistry, Quercetin/chemistry/isolation & purification/pharmacology, Umbelliferones/chemistry/isolation & purification/pharmacology, Vero Cells

Tian,L. W., Pei,Y., Zhang,Y. J., Wang,Y. F., Yang,C. R.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.

http://vp9py7xf3h.search.serialssolutions.com/?charset=utf-8&pmid=19422205

2009